L. Witten

Publications14
h-index8
Citations573
Highly Influential Citations42
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Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.
TLDR
Lu AE58054 is a selective antagonist of 5-HT(6)Rs with good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia, and may be useful for the pharmacotherapy of cognitive dysfunction in disease states such as schizophrenia and Alzheimer's disease.
Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT6 and 5-HT2A receptor mechanisms
TLDR
The efficacies of selective 5-HT2A and5-HT6 receptor antagonists suggest potential mechanisms mediating the effects of sertindole, which has high affinity for these 5- HT receptor subtypes.
HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells
J. Neurochem. (2010) 115, 209–219.
Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved
TLDR
Sertindole and risperidone markedly increased extracellular levels of DA in mPFC, and the built-in 5-HT2A/5- HT2C/D2 receptor antagonism of the two drugs might be involved in this action.
LU AE58054, A POTENT AND SELECTIVE 5-HT6 ANTAGONIST, REVERSES SUBCHRONIC PCP-INDUCED COGNITIVE IMPAIRMENT IN A RAT NOVEL OBJECT RECOGNITION TEST
The effects of acute treatment with escitalopram on the different stages of contextual fear conditioning are reversed by atomoxetine
TLDR
These findings indicate that escitalopram affects fear memory in rats, likely modulated by increases in serotonin levels in the brain, which is impaired by atomoxetine.
HIF prolyl hydroxylase inhibition augments dopamine release in the rat brain in vivo
TLDR
Data indicate that FG0041 augments DA function in the rat brain by increasing DA release, which has implications for the use of HIF induction in the treatment of neurodegenerative diseases.
Comparing Pharmacological Modulation of Sensory Gating in Healthy Humans and Rats: The Effects of Reboxetine and Haloperidol
TLDR
The study indicates that even when experimental conditions are kept as similar as possible, direct human to rat cross-species translation of pharmacological effects on sensory gating is challenging, which calls for more focussed research in this important translational area.
Auditory sensory processing deficits in sensory gating and mismatch negativity-like responses in the social isolation rat model of schizophrenia
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