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Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities
THE Pax genes comprise a family of transcription factors active in specific tissues during embryonic development and are associated with at least three developmental mutations in mouse and man1,2. InExpand
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H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.
H19 and Igf2 are expressed in a monoallelic fashion from the maternal and paternal chromosomes, respectively. A region upstream of H19 has been shown to regulate such imprinted expression of bothExpand
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EIIaCre – Utility of a general deleter strain
We conducted a survey of the utility of the EIIaCre strain of transgenic mice in which Cre is expressed in the unfertilized egg and in the zygote. Our survey is based on results reported by 10Expand
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H 19 and Igf 2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H 19
H19 and Igf2 are expressed in a monoallelic fashion from the maternal and paternal chromosomes, respectively. A region upstream of H19 has been shown to regulate such imprinted expression of bothExpand
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A novel inducible element, activated by contact with Rathke's pouch, is present in the regulatory region of the Rpx/Hesx1 homeobox gene.
Reciprocal inductive interactions are postulated to play a role in the determination and differentiation of the pituitary gland and the ventral hypothalamus. The homeobox gene Rpx/Hesxl is expressedExpand
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An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele.
If deprived of wild-type p53 function, the body loses a guardian that protects against cancer. Restoration of p53 function has, therefore, been proposed as a means of counteracting oncogenesis. ThisExpand
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