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Predictors of Technical Success and Postnatal Biventricular Outcome After In Utero Aortic Valvuloplasty for Aortic Stenosis With Evolving Hypoplastic Left Heart Syndrome
TLDR
Technically successful aortic valvuloplasty alters left heart valvar growth in fetuses with aorti stenosis and evolving hypoplastic left heart syndrome and, in a subset of cases, appeared to contribute to a biventricular outcome after birth.
Brief Intervention for Prenatal Alcohol Use: A Randomized Trial
TLDR
Pregnant women with the highest levels of alcohol use reduced their drinking most after a brief intervention that included their partners, and recommendations include consistent screening for prenatal alcohol use followed by diagnostic assessment when indicated and if confirmed by other studies, a patient-partner brief intervention for the heaviest drinkers.
Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome: Postnatal Outcomes of the First 100 Patients
TLDR
Short- and intermediate-term survival among patients who underwent fetal aortic valvuloplasty and achieved a biventricular circulation postnatally is encouraging, however, morbidity still exists, and ongoing assessment is warranted.
Toluene embryopathy: clinical delineation and developmental follow-up.
TLDR
In utero exposure to toluene seems to be associated with teratogenicity in the developing fetus, and a preliminary picture of toLUene embryopathy is now emerging.
Noninvasive Prenatal Testing and Incidental Detection of Occult Maternal Malignancies
Noninvasive prenatal testing (NIPT) or cell-free DNA (cfDNA) screening can be used to screen for common fetal autosomal aneuploidies. However, NIPT is not a diagnostic test, as cfDNA in the plasma of
Brief intervention for alcohol use in pregnancy: a randomized trial.
TLDR
The importance of screening for prenatal alcohol use is underscored by the findings that any prenatal alcohol consumption increases the risk of continued antepartum drinking.
GPC3 mutation analysis in a spectrum of patients with overgrowth expands the phenotype of Simpson-Golabi-Behmel syndrome.
TLDR
The results validate the clinical specificity of the facial appearance, skeletal/hand anomalies, and supernumerary nipples in patients with GPC3 deletions, and suggest that nephroblastomatosis and hepatoblastoma are included in the phenotypic spectrum of GPC2 deletions and SGBS, underscoring the importance of tumor surveillance in these children.
Teratogen update: toluene.
TLDR
The overlap of features following in utero toluene abuse with those of fetal alcohol syndrome suggests a possible common pathway of craniofacial teratogenesis, and genetic variations that result in deficiency of ALDH2, an enzyme involved in toluenes metabolism, may increase the risks of toLUene teratogenicity in at-risk individuals at lower levels of exposure.
Use of array comparative genomic hybridization for prenatal diagnosis of fetuses with sonographic anomalies and normal metaphase karyotype
TLDR
To prospectively study the addition of array comparative genomic hybridization (CGH) to the prenatal evaluation of fetal structural anomalies, the aim is to establish a baseline for CGH use in pregnancy and establish a protocol for future studies.
Obstetricians and gynecologists' practice and opinions of expanded carrier testing and noninvasive prenatal testing
TLDR
The objective of this study is to assess the opinions of Fellows of the American College of Obstetricians and Gynecologists on expanded carrier testing and noninvasive prenatal testing.
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