• Publications
  • Influence
Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells
Measuring gene expression in individual cells is crucial for understanding the gene regulatory network controlling human embryonic development. Here we apply single-cell RNA sequencing (RNA-Seq)Expand
  • 848
  • 94
The DNA methylation landscape of human early embryos
DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic development. However, its dynamic patterns have not been analysed at the genome scale in humanExpand
  • 492
  • 38
The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells
Germ cells are vital for transmitting genetic information from one generation to the next and for maintaining the continuation of species. Here, we analyze the transcriptome of human primordial germExpand
  • 269
  • 30
Clinical Features of 69 Cases with Coronavirus Disease 2019 in Wuhan, China
Abstract Background From December 2019 to February 2020, 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a serious outbreak of coronavirus disease 2019 (COVID-19) inExpand
  • 302
  • 24
Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote.
The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish full developmental potential.Expand
  • 225
  • 23
Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish.
We describe an enhancer trap transgenic zebrafish line, ETvmat2:GFP, in which most monoaminergic neurons are labeled by green fluorescent protein (GFP) during embryonic development. The reporter geneExpand
  • 142
  • 18
Tracing haematopoietic stem cell formation at single-cell resolution
Haematopoietic stem cells (HSCs) are derived early from embryonic precursors, such as haemogenic endothelial cells and pre-haematopoietic stem cells (pre-HSCs), the molecular identity of which stillExpand
  • 149
  • 14
Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas
Single-cell genome, DNA methylome, and transcriptome sequencing methods have been separately developed. However, to accurately analyze the mechanism by which transcriptome, genome and DNA methylomeExpand
  • 237
  • 11
Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis.
Little is known about how patterns of DNA methylation change during mammalian spermatogenesis. 5 hmC has been recognized as a stable intermediate of DNA demethylation with potential regulatoryExpand
  • 124
  • 11
Synthesis, part of a Special Feature on Resilience and Vulnerability of Arid and Semi-Arid Social Ecological Systems Vulnerability of Worldwide Pastoralism to Global Changes and Interdisciplinary
Ten case studies from seven major pastoral regions across six continents were studied in this paper by conceptualizing three factors (agro-ecosystem resilience, livelihood options, and institutionExpand
  • 140
  • 11