L. Weir

Publications36
h-index22
Citations3,313
Highly Influential Citations32
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Expression of transforming growth factor-beta 1 is increased in human vascular restenosis lesions.
TLDR
Findings are consistent with the concept that transforming growth factor-beta 1 plays an important role in modulating repair of vascular injury, including restenosis, after balloon angioplasty. Expand
Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes.
TLDR
It is shown that the mRNAs encoding the two myosin heavy chain isoforms are differentially expressed in rat nonmuscle and muscle tissues as well as in a number of human cell lines. Expand
Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia.
TLDR
It is suggested that site-specific arterial gene transfer of VEGF165 may achieve physiologically meaningful therapeutic modulation of vascular insufficiency. Expand
Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease.
TLDR
There presently is inadequate evidence from published studies to support the routine use of primary pharmacological treatment in patients with critical leg ischemia, and evidence for the utility of medical therapy in the treatment of claudication is no better. Expand
Proliferative activity in peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularization.
TLDR
It is concluded that cellular proliferation is a feature of atherosclerotic lesions which are associated with symptoms of ischemia, but that it is more prominent in restenosis compared to primary lesions, particularly after percutaneous revascularization. Expand
Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.
TLDR
It is found that there is a B-cell-specific enhancer-activator region in the J-C intron of the human kappa gene that is necessary for efficient transcription of the cloned gene in mouse pre-B lymphocytes, suggesting that both the DNA element and the proteins required for its regulatory activity have been highly conserved in evolution. Expand
Percutaneous arterial gene transfer in a rabbit model. Efficiency in normal and balloon-dilated atherosclerotic arteries.
TLDR
In situ hybridization of successfully transfected atherosclerotic sections showed expression of the luciferase gene mRNA from rare cells (less than 1/1,000) limited to the neointimal lesion, indicating that expression of new genetic material may be achieved in both normal and balloon-dilated atherosclerosis arteries following an exclusively percutaneous approach. Expand
Relation between activated smooth-muscle cells in coronary-artery lesions and restenosis after atherectomy.
TLDR
The expression of the B isoform of nonmuscle myosin heavy chain is increased in some coronary atherosclerotic plaques and that this increase in expression identifies a group of lesions at high risk for restenosis after atherectomy. Expand
Increased gene expression after liposome-mediated arterial gene transfer associated with intimal smooth muscle cell proliferation. In vitro and in vivo findings in a rabbit model of vascular injury.
TLDR
Findings indicate that the expression of liposome-mediated arterial gene transfer may be augmented in presence of ongoing cellular proliferation, as shown in rabbits with or without antecedent angioplasty. Expand
Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model.
TLDR
These cultured cells represent a population in which the activating function of c-myc can be uncoupled from secondary oncogenic events occurring in vivo, and apparently the isolated enhancer targets oncogene expression and tumorigenesis to the early B-cell population in preference to more mature B- cell populations. Expand
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