• Publications
  • Influence
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.
TLDR
These studies uncover a mechanism by which BAF155 acquires tumorigenic functions via arginine methylation, which is found to be an independent prognostic biomarker for cancer recurrence and to regulate breast cancer cell migration and metastasis.
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.
TLDR
It is demonstrated that SPOP, which encodes an E3 ubiquitin ligase component, is a direct transcriptional target of HIFs in clear cell renal cell carcinoma (ccRCC), and Knockdown of SPOP specifically kills ccRCC cells, indicating that it may be a promising therapeutic target.
RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay.
TLDR
This study discovered that Y-box binding protein 1 (Ybx1) preferentially recognizes m5C-modified mRNAs through π-π interactions with a key residue, Trp45, in YbX1's cold shock domain (CSD), which plays essential roles in maternal mRNA stability and early embryogenesis of zebrafish.
Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect?
TLDR
Curcumin can prevent and ameliorate NASH via lipid reduction, improve insulin resistance, improve anti-inflammatory, and have antioxidant effects, possibly related to its activation of Nrf2.
Diagnostic and prognostic value of plasma microRNA deregulation in nasopharyngeal carcinoma
TLDR
Plasma miRNA expression is a useful biomarker for NPC diagnosis but not for its prognosis, and combination of several plasma miRNAs can increase both NPC diagnostic sensitivity and specificity.
Expression and prognostic significance of placental growth factor in hepatocellular carcinoma and peritumoral liver tissue
TLDR
High peritumoral PlGF expression is associated with tumor recurrence and survival after resection of HCC, and could be a target of adjuvant therapy and deserves further investigations.
BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells.
TLDR
DUSP9 is identified as a critical mediator of BMP signaling to control appropriate ERK activity critical for ESC fate determination, which reinforces the self-renewal status of mouse ESCs together with LIF.
Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy
TLDR
The data dissociate myocyte hypertrophy, a consistent response in HCM, from heterogeneous Mef2 activation and reexpression of a fetal gene program, which defines Mef1 activation as a molecular signature of stressed HCM myocytes that are poised to die.
CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis.
TLDR
The authors regret this error and apologize for any confusion that it may have caused to the readers.
miR-106a promotes cardiac hypertrophy by targeting mitofusin 2.
TLDR
The findings of this study indicate miR-106a as an important factor to promote hypertrophic progress and suggest miR/Mfn2 as a new molecular target for the treatment of pathological hypertrophy.
...
1
2
3
4
5
...