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Plasma miR-601 and miR-760 Are Novel Biomarkers for the Early Detection of Colorectal Cancer
Background Colorectal cancer (CRC) is a major cause of death worldwide. Sensitive, non-invasive diagnostic screen methods are urgently needed to improve its survival rates. Stable circulating… Expand
Dysregulation of the IL-23/IL-17 axis and myeloid factors in secondary progressive MS
Objective: In the current exploratory study, we longitudinally measured immune parameters in the blood of individuals with relapsing-remitting multiple sclerosis (RRMS) and secondary progressive… Expand
MicroRNA-95 promotes cell proliferation and targets sorting Nexin 1 in human colorectal carcinoma.
MicroRNAs (miRNAs) are strongly implicated in cancer but their specific roles and functions in the major cancers have yet to be fully elucidated. In this study, we defined the oncogenic significance… Expand
CD133: a potential indicator for differentiation and prognosis of human cholangiocarcinoma
BackgroundCD133 is known to be a cancer stem cell (CSC) marker. However, recent studies have revealed that CD133 is not restricted to CSC but to be expressed not only in human normal tissues but also… Expand
Biomarkers in bladder cancer: translational and clinical implications.
Bladder cancer is associated with high recurrence and mortality rates. These tumors show vast heterogeneity reflected by diverse morphologic manifestations and various molecular alterations… Expand
Synthesis and c-Met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a…
- Yuanxiang Wang, Jing Ai, +5 authors A. Zhang
- Medicine, Chemistry
- Journal of medicinal chemistry
- 15 March 2011
By use of an improved synthetic strategy, a series of 3,5-disubstituted and 3,5,7-trisubstituted quinolines were readily prepared. 3,5,7-Trisubstituted quinolines 21a-c, 21l, and 27a-c were… Expand
Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant…
Metanephric adenoma is a benign renal neoplasm that overlaps in morphology with the solid variant of papillary renal cell carcinoma and epithelial-predominant nephroblastoma. To aid in resolving this… Expand
MicroRNA-142-5p contributes to Hashimoto’s thyroiditis by targeting CLDN1
BackgroundMicroRNAs have the potential as diagnostic biomarkers and therapeutic targets in autoimmune diseases. However, very limited studies have evaluated the expression of microRNA profile in… Expand
Extraction, characterization and antioxidant activity of water-soluble polysaccharides from Tuber huidongense.
- Guangjing Chen, Shiqi Zhang, Chunxia Ran, L. Wang, J. Kan
- Medicine, Chemistry
- International journal of biological…
- 1 October 2016
Single-factor experiment and Box-Behnken design were employed to optimize the ultrasonic-assisted extraction (UAE) of water-soluble polysaccharides from Chinese truffle Tuber huidongense (THWP). The… Expand
FOXM1 Promotes Lung Adenocarcinoma Invasion and Metastasis by Upregulating SNAIL
- P. Wei, N. Zhang, +7 authors X. Du
- Biology, Medicine
- International journal of biological sciences
- 5 January 2015
The forkhead box M1 (FOXM1) transcription factor is one of the key genes inducing tumor invasion and metastasis by an unknown mechanism. In this study, we set out to investigate the effects of FOXM1… Expand