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Inactivation of O6-alkylguanine-DNA alkyltransferase in HeLa cells by cisplatin.
TLDR
The data suggest that the O 6-platinum-guanine formation and the O6-alkyltransferase depletion are not responsible for cytotoxicity but may result in a base substitution mutation in mammalian cells. Expand
The Limbic-Prefrontal Network Modulated by Electroacupuncture at CV4 and CV12
TLDR
This fMRI study investigated acupuncture's modulation effects on brain functional networks by electroacupuncture at acupoints on the midline of abdomen and found that the limbic-prefrontal functional network was deactivated by EA at CV4 and CV12. Expand
Large-scale gene losses underlie the genome evolution of parasitic plant Cuscuta australis
TLDR
The authors sequence the genome of Cuscuta australis and find remarkable gene loss associated with parasitic lifestyle and large changes in body plan, which is likely result from its parasitic lifestyles and the massive changes of its body plan. Expand
Strigolactone and Karrikin Signaling Pathways Elicit Ubiquitination and Proteolysis of SMXL2 to Regulate Hypocotyl Elongation in Arabidopsis[OPEN]
  • L. Wang, Qian Xu, +10 authors B. Wang
  • Medicine, Biology
  • Plant Cell
  • 30 April 2020
TLDR
It is demonstrated that both SLs and Karrikins could trigger polyubiquitination and degradation of SMXL2, thus uncovering an unexpected but important convergent pathway in SL- and KAR-regulated gene expression and hypocotyl elongation. Expand
Genome-Wide Epigenetic Regulation of Gene Transcription in Maize Seeds
TLDR
The study helps people better understand from a genome-wide viewpoint that how transcriptional expression is controlled by DNA methylation, one of the important factors influencing transcription, and how the methylation is associated with small RNAs. Expand
Large-scale collection and annotation of gene models for date palm (Phoenix dactylifera, L.)
TLDR
A large-scale effort is reported in generating gene models (assembled expressed sequence tags or ESTs and mapped to a genome assembly) for P. dactylifera, using the long-read pyrosequencing platform (Roche/454 GS FLX Titanium) in high coverage. Expand
A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2
TLDR
Results provide a proof-of-concept for neutralization-based immunogen design targeting SARS-CoV-2 NTD and RBD, and results of competitive SPR assays and cryo-EM structures of Fabs bound to S unveil determinants of immunogenicity. Expand
Magnesium Contamination in Soil at a Magnesite Mining Region of Liaoning Province, China
TLDR
Lab experiment revealed that anionic polyacrylamide and calcium dihydrogen phosphate can be used to improve soil condition, and have positive effects on soil function, providing clear options for the remediation of soils. Expand
The risk of carcinogenesis in congenital choledochal cyst patients: an analysis of 214 cases.
TLDR
Choledochal cysts should be removed once diagnosed because of an increased risk of malignant transformation with increasing age, and additional hepatectomy should be considered for type IVa choledochAl cysts because cholangiocarcinoma can arise from the intrahepatic bile duct years after the extrahePatic cyst excision. Expand
Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions
TLDR
Several integration-free clinical-grade hiPSCs lines are derived under GMP-controlled conditions and with Xeno-free reagents culture media in line with the current guidance of international and national evaluation criteria and could be valuable sources for future hiPSC-based clinical trials or therapies and for drug screening. Expand
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