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A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays.
We have developed a robust algorithm for copy number analysis of the human genome using high-density oligonucleotide microarrays containing 116,204 single-nucleotide polymorphisms. The advantages ofExpand
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SF3B1 and other novel cancer genes in chronic lymphocytic leukemia.
BACKGROUND The somatic genetic basis of chronic lymphocytic leukemia, a common and clinically heterogeneous leukemia occurring in adults, remains poorly understood. METHODS We obtained DNA samplesExpand
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Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia
Clonal evolution is a key feature of cancer progression and relapse. We studied intratumoral heterogeneity in 149 chronic lymphocytic leukemia (CLL) cases by integrating whole-exome sequence and copyExpand
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Oncogenic mutations of ALK kinase in neuroblastoma
Neuroblastoma in advanced stages is one of the most intractable paediatric cancers, even with recent therapeutic advances. Neuroblastoma harbours a variety of genetic changes, including a highExpand
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Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo.
  • W. Noble, E. Planel, +14 authors K. Duff
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 10 May 2005
Neurofibrillary tangles composed of hyperphosphorylated, aggregated tau are a common pathological feature of tauopathies, including Alzheimer's disease. Abnormal phosphorylation of tau by kinases orExpand
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Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is critical for the differentiation of CD4− CD8− thymocytes to CD4+CD8+Expand
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Cdk5 Is a Key Factor in Tau Aggregation and Tangle Formation In Vivo
Tau aggregation is a common feature of neurodegenerative diseases such as Alzheimer's disease, and hyperphosphorylation of tau has been implicated as a fundamental pathogenic mechanism in thisExpand
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Health risk of heavy metals in food crops grown on reclaimed tidal flat soil in the Pearl River Estuary, China.
The health risks of heavy metals to local residents via consumption of food crops cultivated in the reclaimed soils of the Pearl River Estuary (PRE) were investigated. Soils in the river estuary wereExpand
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Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial.
Leber congenital amaurosis (LCA) is a group of autosomal recessive blinding retinal diseases that are incurable. One molecular form is caused by mutations in the RPE65 (retinal pigmentExpand
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Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing
Cyclin-dependent kinase 5 (cdk5) has been implicated in Alzheimer's disease (AD) pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1Expand
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