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CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high- incidence area in north China.
- L. Wang, S. Zheng, B. Liu, Jian-Xiang Zhou, Y. Li, Ji-Xue Li
- World journal of gastroenterology
- 15 July 2003
AIM To characterize cytochrome P4501A1 (CYP1A1), glutathione S-transferases (GSTs) and microsomal epoxide hydrolase (mEH) polymorphisms in Chinese esophageal cancer patients. METHODS Multiplex… Expand
Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma.
Esophageal cancer ranks sixth in cancer death. To explore its genetic origins, we conducted exomic sequencing on 11 esophageal adenocarcinomas (EAC) and 12 esophageal squamous cell carcinomas (ESCC)… Expand
CYP2A13 in Human Respiratory Tissues and Lung Cancers: An Immunohistochemical Study with A New Peptide-Specific Antibody
- Liang-ru Zhu, P. Thomas, +7 authors J. Hong
- Medicine, Biology
- Drug Metabolism and Disposition
- 1 October 2006
Human cytochrome P450 2A13 (CYP2A13) is highly efficient in the metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and another potent… Expand
Circulating microRNAs: novel biomarkers for esophageal cancer.
Esophageal carcinogenesis is a multi-stage process, involving a variety of changes in gene expression and physiological structure change. MicroRNAs (miRNAs) are a class of small non-coding endogenous… Expand
Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression
Bromodomain 4 (BRD4) is an epigenetic regulator that, when inhibited, has anti-cancer effects. In this study, we investigated whether BRD4 could be a target for treatment of human hepatocellular… Expand
Deciphering the signature of selective constraints on cancerous mitochondrial genome.
- J. Liu, L. Wang, +5 authors Qingpeng Kong
- Medicine, Biology
- Molecular biology and evolution
- 1 April 2012
In accordance with the hypothesis that cancer formation is a process of somatic evolution driven by natural selection, signature of positive selection has been detected on a number of cancer-related… Expand
Relevance of serum estradiol and estrogen receptor beta expression from a high-incidence area for esophageal squamous cell carcinoma in China
The striking 3-4:1 male predominance of esophageal squamous cell carcinoma (ESCC) has not yet been well explained. Our hypothesis is that the changes in level of estrogen and/or subtype of estrogen… Expand
Primary adenocarcinomas of lower esophagus, esophagogastric junction and gastric cardia: in special reference to China.
Gastric cardia adenocarcinoma (GCA) is an under-studied subject. The pathogenesis, molecular changes in the early stage of carcinogenesis and related risk factors have not been well characterized.… Expand
Detection of multiple gene hypermethylation in the development of esophageal squamous cell carcinoma.
Abnormal hypermethylation of CpG islands associated with tumor suppressor genes can lead to repression of gene expression and contribute significantly to tumorigenesis. Esophageal squamous cell… Expand
[Chromosomal aberration analyzed by comparative genomic hybridization in nasopharyngeal carcinoma].
- Z. Li, L. Wang, +9 authors G. Li
- Biology, Medicine
- Zhonghua yi xue yi chuan xue za zhi = Zhonghua…
- 1 October 2001
OBJECTIVE To identify genetic alteration in primary sporadic nasopharyngeal carcinoma(NPC) in Hunan. METHODS Comparative genomic hybridization was applied to investigate the genomic imbalance in a… Expand