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Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity
The rapidly emerging field of nanotechnology has offered innovative discoveries in the medical, industrial, and consumer sectors. The unique physicochemical and electrical properties of engineeredExpand
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Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes
BackgroundMulti-walled carbon nanotubes (MWCNTs) are new manufactured nanomaterials with a wide spectrum of commercial applications. To address the hypothesis that MWCNTs cause persistent pulmonaryExpand
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Extrapulmonary transport of MWCNT following inhalation exposure
BackgroundInhalation exposure studies of mice were conducted to determine if multi-walled carbon nanotubes (MWCNT) distribute to the tracheobronchial lymphatics, parietal pleura, respiratoryExpand
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Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan
To investigate the carcinogenic effect of environmental aflatoxin exposure, 56 cases of hepatocellular carcinoma (HCC) diagnosed between 1991 and 1995 were identified and individually matched by age,Expand
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Characteristics of organic phosphorus fractions in different trophic sediments of lakes from the middle and lower reaches of Yangtze River region and Southwestern Plateau, China.
In this study, the characteristics of organic phosphorus (Po) fractions in sediments of six lakes from the middle and lower reaches of Yangtze River region and Southwestern China Plateau, China wereExpand
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Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells.
Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubesExpand
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S-Nitrosylation of Bcl-2 Inhibits Its Ubiquitin-Proteasomal Degradation
Bcl-2 is a key apoptosis regulatory protein of the mitochondrial death pathway whose function is dependent on its expression levels. Although Bcl-2 expression is controlled by various mechanisms,Expand
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Interleukin-10-mediated inhibition of free radical generation in macrophages.
Interleukin-10 (IL-10) is a pleiotropic cytokine that controls inflammatory processes by suppressing the production of proinflammatory cytokines that are known to be transcriptionally regulated byExpand
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Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes
BackgroundMulti-walled carbon nanotubes (MWCNT) are new manufactured nanomaterials with a wide spectrum of commercial applications. The durability and fiber-like dimensions (mean length 3.9 μm long ×Expand
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Nitric Oxide Negatively Regulates Fas CD95-induced Apoptosis through Inhibition of Ubiquitin-Proteasome-mediated Degradation of FLICE Inhibitory Protein*
Stimulation of cell surface Fas (CD95) results in recruitment of cytoplasmic proteins and activation of caspase-8, which in turn activates downstream effector caspases leading to programmed cellExpand
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