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IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway
Although the Th17 subset and its signature cytokine, interleukin (IL)-17A (IL-17), are implicated in certain autoimmune diseases, their role in cancer remains to be further explored. IL-17 has beenExpand
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The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice.
Cardiac hypertrophy and failure are accompanied by a reprogramming of gene expression that involves transcription factors and chromatin remodeling enzymes. Little is known about the roles of histoneExpand
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AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function.
Diabetic microvascular complications have been considered to be mediated by a glucose-driven increase in mitochondrial superoxide anion production. Here, we report that superoxide production wasExpand
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Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model
Background Autism spectrum disorders (ASDs) are caused by both genetic and environmental factors. Mitochondria act to connect genes and environment by regulating gene-encoded metabolic networksExpand
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Potential markers that complement expression of CA125 in epithelial ovarian cancer.
BACKGROUND When ovarian carcinoma is diagnosed in stage I, up to 90% of patients can be cured with surgery and currently available chemotherapy. At present, less than 25% of cases are diagnosed atExpand
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Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats.
We investigated the toxic effects of inhalation exposure to ferric oxide (Fe2O3) and zinc oxide (ZnO) nanoparticles in rats. Male Wistar rats were consecutively treated with Fe22O3 at 8.5 mg/kg bodyExpand
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Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors.
Cationic lipid-mediated intravenous gene delivery shows promise in treating pulmonary diseases including lung tumor metastases, pulmonary hypertension, and acute respiratory distress syndrome.Expand
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The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II.
PFIC II is a subtype of progressive familial intrahepatic cholestasis (PFIC) that is associated with mutations in the ABCB11 gene encoding the bile salt export pump (BSEP). However it is not knownExpand
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Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats.
BACKGROUND & AIMS Capillarization, characterized by loss of differentiation of liver sinusoidal endothelial cells (LSECs), precedes the onset of hepatic fibrosis. We investigated whether restorationExpand
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Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations
Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer characterized by Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The scarcity of NPC genomic data hindersExpand
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