Effects of a new cholinolytic drug of tropanes and its optical isomers on central muscarinic and nicotinic receptors.
Anticholinergic Activity in Mice and Receptor‐binding Properties in Rats of a Series of Synthetic Tropane Derivatives
- Z. Gao, W. Cui, B. Y. Liu, C. Liu, L. Wang
- Chemistry, BiologyThe Journal of pharmacy and pharmacology
- 1 March 1997
A tropane ester, three tropane ethers, atropine and mecamylamine were compared in mice for their anti‐muscarinic and anti‐nicotinic activity against arecoline‐induced tremor and nicotine‐induced…
Pharmacological activity and receptor-binding characteristics of 2 beta-(2'-phenyl-2'-cyclopentyl-2'-hydroxy-ethoxy)tropane and its optical isomers.
- Z. Gao, W. Cui, L. Wang, C. Liu
- Biology, ChemistryArchives internationales de pharmacodynamie et de…
- 1 March 1996
The findings indicate that beta-PCT and its optical isomers are useful affinity ligands to examine the biochemical and functional characteristics of brain cholinergic receptors.
Allosteric and competitive interactions of 2 alpha-(2',2'-disubstituted- hydroxy-ethoxy)tropane and its optical isomers at rat central muscarinic acetylcholine receptors.
Both allosteric and competitive interactions of 2 alpha-DHET and its four optical isomers with muscarinic acetylcholine receptors in rat cerebral cortex were investigated but the competitive binding potencies of these compounds were significantly different.
Functional sites of the nicotinic acetylcholine receptor.
Effects of 2 alpha-DHET and its optical isomers on muscarinic and nicotinic receptors.
A good correlation was observed between the affinities to muscarinic receptors and the antimuscarinic potencies in isolated guinea pig ileum and the binding data for 2 alpha-DHET and its isomers were consistent with their central and peripheral pharmacological activity in vivo.