Histochemistry of mucosubstances in the canine and human respiratory tract.
Effect of chronic sulfur dioxide inhalation on the carbohydrate histochemistry and histology of the canine respiratory tract.
Lungs of dogs were examined morphologically and histochemically after chronic inhalation of sulfur dioxide (SO2), and squamous metaplasia, which was most prominent and diffuse in the proximal trachea and focal in the more distal respiratory tract, differed from normal oropharyngeal stratified squamous epithelium in its formation of sulfated mucosubstance.
The subcellular distribution of (N-Me-3H)acetylcholine synthesized by brain in vivo.
It is concluded that the various forms of acetylcholine could not have arisen during fractionation from a single pre-existing pool of acetelcholine.
Pharmacologic regulation of antigen-induced mediator release from canine lung.
It is concluded that fragmented canine lung, while disclosing some qualitative pharmacological differences from other species, is a useful in vitro model of immediate hypersensitivity reactions.
Ultrastructural and histochemical observations of respiratory epithelium and gland.
Heterogeneity of cells can be demonstrated in the serous and mucous tubules by ultrastructural, morphologic, and cytochemical methods.
The canine tracheal pouch. A model for use in respiratory mucus research.
Antiarthritic properties and unique pharmacologic profile of a potential chrysotherapeutic agent: S K & F D-30162.
- D. T. Walz, M. Dimartino, L. W. Chakrin, B. Sutton, A. Misher
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 April 1976
In pharmacokinetic studies, the daily oral administration of SK&F D-39162 to normal rats produced greater stability of blood gold levels and less kidney gold accumulation than parenterally administered gold sodium thiomalate.
Effect of cholinergic stimulation on the release of macromolecules by canine trachea in vitro.
- L. W. Chakrin, A. P. Baker, P. Christian, J. R. Wardell
- Biology, MedicineAmerican Review of Respiratory Disease
- 1 July 1973
Addition of acetylcholine chloride to the bath fluid significantly increased the release of total [3H] macromolecules, presumably by stimulation of cholinergically innervated submucosal mucous glands, an effect that could be pharmacologically antagonized by atropine sulfate.
C5a-induced histamine release. Species specificity.
- J. Regal, T. Hardy, F. Casey, L. W. Chakrin
- Biology, MedicineInternational Archives of Allergy and Applied…
The differences between reactivity of species to C5a are emphasized and the danger of extrapolating results obtained in one animal species to models employed with another species is emphasized.
Canine airway responses to acetylcholine, prostaglandin F2alpha, histamine, and serotonin after chronic antigen exposure.