• Publications
  • Influence
Antihypertensive activity of an alkyl ether analog of phosphatidylcholine.
Summary An alkyl ether analog of phosphatidylcholine was prepared from choline plasmalogen of fresh beef heart by reducing the alk-1-enyl moiety to an alkyl group and by hydrolyzing the sn -2 acylExpand
Antihypertensive Polar Renomedullary Lipid, A Semisynthetic Vasodilator
TLDR
Hemodynamic studies indicate that both the acute and prolonged effect of APRL causes vasodilatation with minimal or no tachycardia, and preliminary studies fail to reveal acute toxiclty. Expand
Antihypertensive lipids from the kidney: alkyl ether analogs of phosphatidylcholine.
Four types of lipids with potential antihypertensive properties have recently been derived from the kidney. These consist of prostaglandins (PG), a renin inhibitor, a neutral lipid, and alkyl etherExpand
Cardiovascular effects of antihypertensive renomedullary lipids (APRL and ANRL).
Reversal of hypertension by transplants and lipid extracts of cultured renomedullary interstitial cells.
TLDR
The lowering of the hypertensive pressure before there was vascularization of the transplant appears to support the view that the transplanted cells secreted and/ or liberated an antihypertensive substance(s) that seeped out and was absorbed by nearby capillaries and/or lymphatics and circulated and acted in the manner of a hormone. Expand
Pharmacological and biological psychotherapy.
Data we have collected suggesting that schizophrenia is a deficiency disorder in the area of amine metabolism are presented. Investigations are currently under way toward finding substances whichExpand
SECRETION OF MEDULLIPIN I BY ISOLATED KIDNEYS PERFUSED UNDER ELEVATED PRESSURE
1. Medullipin I (Med I) is a hormone extracted from renal papillae and its renomedullary interstitial cells (RIC). Med I is stimulated by elevation of the renal artery perfusion pressure.
Purification of class I medullipins from the venous effluent of isolated normal kidneys perfused under high pressure with saline.
TLDR
The results show that Med I, as defined by previous physiologic and pharmacologic criteria, is not a single molecule. Expand
Biologic differences between vasodilator prostaglandins and medullipin I.
TLDR
It is concluded that Med I and vasodilator PGs of the kidney are separate and distinct biologic entities. Expand
Medullipin System Generation of Medullipin II by Isolated Kidney‐Liver Perfusion
TLDR
Findings support the view that medullipin II is the final product of the renohepatic axis of blood pressure control. Expand
...
1
2
3
4
...