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- Publications
- Influence
Minocycline effect on life and health span of Drosophila melanogaster.
- G. Oxenkrug, V. Navrotskaya, L. Vorobyova, P. Summergrad
- Biology, Medicine
- Aging and disease
- 1 May 2012
Up-regulation of kynurenine (KYN) pathway of tryptophan (TRP) was suggested as one of the mechanisms of aging and aging-associated disorders. Genetic and pharmacological impairment of TRP - KYN… Expand
Attenuation of high sucrose diet-induced insulin resistance in tryptophan 2,3-dioxygenase deficient Drosophila melanogaster vermilion mutants.
- V. Navrotskaya, G. Oxenkrug, L. Vorobyova, P. Summergrad
- Biology, Medicine
- Integrative obesity and diabetes
- 2015
Exposure to high sugar diet (HSD) serves as an experimental model of insulin resistance (IR) and type 2 diabetes (T2D) in mammals and insects. Peripheral IR induced by HSD delays emergence of pupae… Expand
Berberine Prolongs Life Span and Stimulates Locomotor Activity of Drosophila melanogaster.
- V. Navrotskaya, G. Oxenkrug, L. Vorobyova, P. Summergrad
- Biology, Medicine
- American journal of plant sciences
- 17 July 2012
Drosophila melanogaster mutants with deficient kynurenine (KYN) formation from tryptophan (TRP) have longer life span than wild type flies. Administration of alpha-methyl-TRP and 5-methyl-TRY, the… Expand
Berberine Attenuated Aging-Accelerating Effect of High Temperature in Drosophila Model
- V. Navrotskaya, G. Oxenkrug, L. Vorobyova, P. Summergrad
- Biology, Medicine
- American journal of plant sciences
- 26 January 2014
We have observed that berberine prolonged life span and improved viability of pupae and climbing activity of imagoes of wild-type Drosophila melanogaster maintained at 23°C. As a continuation of our… Expand
Cerebrolysin Accelerates Metamorphosis and Attenuates Aging-Accelerating Effect of High Temperature in Drosophila Melanogaster.
- V. Navrotskaya, G. Oxenkrug, L. Vorobyova, H. Sharma, D. Muresanu, P. Summergrad
- Biology, Medicine
- American journal of neuroprotection and…
- 1 October 2014
Cerebrolysin® (CBL) is a neuroprotective drug used for the treatment of neurodegenerative diseases. CBL's mechanisms of action remain unclear. Involvement of tryptophan (TRP)-kynurenine (KYN) pathway… Expand
Attenuation of high sucrose diet-induced insulin resistance in ABC transporter deficient white mutant of Drosophila melanogaster.
- V. Navrotskaya, G. Oxenkrug, L. Vorobyova, P. Summergrad
- Biology, Medicine
- Integrative obesity and diabetes
- 8 February 2016
Exposure to high sugar diet (HSD) is an experimental model of insulin resistance (IR) and type 2 diabetes (T2D) in mammals and insects. In Drosophila, HSD-induced IR delays emergence of pupae from… Expand