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  • Influence
C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study.
TLDR
Baseline CRP levels seem to be a biomarker of chronic inflammation preceding lung cancer, even after subtracting a 5-year latent period, and both chronic inflammation and impaired defense mechanisms resulting in chronic inflammation might explain these results. Expand
Lower Risk of Cancer in Patients on Metformin in Comparison With Those on Sulfonylurea Derivatives
TLDR
Cumulative exposure to metformin was associated with a lower risk of specific cancers and cancer in general, compared with cumulative exposure to sulfonylurea derivatives. Expand
Hospitalisations and emergency department visits due to drug–drug interactions: a literature review
TLDR
The incidence of adverse patient outcomes due to drug–drug interactions (D–DIs), the type of drugs involved and the underlying reason were evaluated, and emergency department visits, hospital admissions and re‐hospitalisations were assessed. Expand
Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study
TLDR
The results suggest that the transporter MATE1, encoded by SLC47A1, may have an important role in the pharmacokinetics of metformin, although replication is necessary. Expand
Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large population-based follow-up study
TLDR
Users of insulin glargine and users of other insulin analogues had a lower risk of cancer in general than those using human insulin, and an increased risk of breast cancer in users of insulinglargine in comparison with users of human insulin. Expand
A genome-wide association study of acenocoumarol maintenance dosage.
TLDR
It is confirmed that acenocoumarol dosage mainly depends on polymorphisms in the VKORC1 and CYP2C9 genes, and genetic variation in the cytochrome P450 2C18 (CYP2C18) gene contributing to variance of acenOCou marol dosage. Expand
The CYP2D6*4 polymorphism affects breast cancer survival in tamoxifen users
TLDR
The risk of breast cancer mortality is increased in tamoxifen users with decreased CYP2D6 activity, consistent with the model in which endoxifens formation is dependent on CYP 2D6 action. Expand
High-ceiling diuretics are associated with an increased risk of basal cell carcinoma in a population-based follow-up study.
TLDR
Cumulative use of high-ceiling diuretics was associated with an increased risk of diagnosis of basal cell carcinoma, and this effect is stronger in patients who easily get sunburned. Expand
The risk of overanticoagulation in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon.
TLDR
Investigation of CYP2C9 polymorphisms in relation to the international normalized ratio (INR) during the first 6 weeks of treatment and its effect on the maintenance dose in a cohort of 1124 patients from the Rotterdam Study found Phenprocoumon appears to be a clinically useful alternative in patients carrying the CYP 2C9*2 and *3 alleles. Expand
Acute renal failure after local gentamicin treatment in an infected total knee arthroplasty.
TLDR
Use of this procedure in elderly patients warrants careful follow-up of renal function, and the combined use of beads and a cement block spacer, both gentamicin impregnated, may have induced this severe complication. Expand
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