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A phase I study of the safety and tolerability of VLX600, an Iron Chelator, in patients with refractory advanced solid tumors
TLDR
VLX600 was reasonably well tolerated and, together with preclinical data, there is support for further efforts to explore its activity as single agent and in combination with drugs or radiation. Expand
Aberrant lipid metabolism as a therapeutic target in liver cancer
TLDR
HCC demonstrates significant alteration in lipid metabolism, representing great potential as a target for novel therapeutics, and the promise of multiple targets, in particular related to HCC treatment. Expand
Reader response: Association between aspirin dose and subarachnoid hemorrhage from saccular aneurysms: A case-control study
TLDR
The effect of aspirin in preventing acute subarachnoid hemorrhage from intracranial aneurysm rupture is well-studied but with the advent of endovascular and neurosurgical procedures, the data on aspirin use and rerupture are definitively unknown. Expand
A Rare Case of RYR2 Mutation Causing Sudden Cardiac Arrest Due to Catecholaminergic Polymorphic Ventricular Tachycardia
TLDR
A case of CPVT is reported in a patient with RYR2 gene mutation, causing sudden cardiac arrest, and avoidance of strenuous activities and pharmacological therapy with beta-blockers are the mainstays of treatment. Expand
Lung Adenocarcinoma Presenting as Malignant Pericardial Effusion/Tamponade
TLDR
A 57-year-old female presenting with cardiac tamponade and subsequent testing was done which revealed lung adenocarcinoma, which is one of the most common primary tumors that involve the pericardium with a prevalence of up to 50%. Expand
Metastatic renal cell carcinoma complicated by right atrial thrombus
TLDR
A case of renal cell carcinoma presenting with progressive fatigue, abdominal pain, and weight loss is presented and complex renal mass with extension to right atrium and histopathology confirmed the metastatic renal cell cancer. Expand
Metastatic renal cell carcinoma complicated by right atrial thrombus
TLDR
A case of renal cell carcinoma presenting with progressive fatigue, abdominal pain, and weight loss is presented and complex renal mass with extension to right atrium is revealed. Expand
Is the Renal Resistive Index a Marker for Revascularization in Atherosclerotic Renal Artery Stenosis?
TLDR
It is believed that renal resistive index with supportive clinical, laboratory, and imaging modalities can help select revascularization patients. Expand
The role of anticoagulant therapy in hemorrhagic transformation of acute ischaemic stroke in nonvalvular atrial fibrillation patients
TLDR
This study showed a significantly lower risk of symptomatic hemorrhagic transformation (HT) of acute ischaemic stroke in nonvalvular atrial fibrillation patients on direct oral anticoagulants (DOACs) than on patients on vitamin K antagonists (VKAs). Expand
Left Ventricular Assist Device Therapy and Acute Pancreatitis
TLDR
Patients with LVAD have double risk of pancreatitis, worse clinical outcomes, and increased healthcare utilization, and studies elucidating the mechanisms behind pancreatic injury in advanced heart failure are suggested. Expand
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