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In our earlier investigation  of 2,3,4-trisubstituted pyridines with the amino and amidino groups at the 2and 4-positions, we discovered compounds having analgetic activity. In continuation of… (More)
A number of 4-oxo-1,4-dihydro-1,8-naphthyridine derivatives that differ with respect to the sizes of the azaand carbocycles were synthesized by the reaction of… (More)
The reactions of 4-carbamoyl- and 4-cyanopyridin-3-one and 4-cyanoisoquinolin-3-one with DMFA diethyl acetal were studied, and hydrogenated di- and trimethylene derivatives of… (More)
the synthesized compounds and the reference preparation, are given in Table I. It is evident that with daily injection in a dose of 5 mg/kg for 7 days, all compounds studied inhibited the formation… (More)
A current area of interest in the search for drugs for the treatment of cardiovascular diseases is the preparation of compounds which combine 8-adrenoblocking properties with ~adrenobloeking and… (More)
(IV, 10% yield, mp 174-176=C, from CHsCN ). The structure of IV was proved by independent synthesis from 5,6,7,8-tetrahydro-4-eyano-3-ethoxyisoquinoline (V, mp 78-79~ from hexane) which, in turn, was… (More)