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Excessive Adipose Tissue Infiltration in Skeletal Muscle in Individuals With Obesity, Diabetes Mellitus, and Peripheral Neuropathy: Association With Performance and Function
- T. Hilton, L. Tuttle, Kathryn L. Bohnert, Michael J. Mueller, D. Sinacore
- Physical Therapy
- 1 November 2008
The data indicate that excess fat infiltration in leg skeletal muscles is associated with low calf muscle strength, low calf Muscle strength, and impaired physical function in individuals who are obese with DM and PN. Expand
Intermuscular Adipose Tissue Is Muscle Specific and Associated with Poor Functional Performance
IMAT accumulation varies in calf muscles, is highest in the gastrocnemius muscle, and is associated with poor physical performance, which is inversely related to physical performance. Expand
Plantar Stresses on the Neuropathic Foot During Barefoot Walking
- Michael J. Mueller, Dequan Zou, Kathryn L. Bohnert, L. Tuttle, D. Sinacore
- Physical Therapy
- 1 November 2008
Background and Purpose: Patients with diabetes mellitus and peripheral neuropathy are at high risk for plantar skin breakdown due to unnoticed plantar stresses during walking. The purpose of this… Expand
Muscle imbalance and reduced ankle joint motion in people with hammer toe deformity.
The ratio of toe extensor/flexor toe muscle strength ratio was 2.3-3.0 times higher in the hammer toe group compared to the non-hammer toe group, in toes 2-4. Expand
Weight-bearing versus nonweight-bearing exercise for persons with diabetes and peripheral neuropathy: a randomized controlled trial.
- Michael J. Mueller, L. Tuttle, +4 authors D. Sinacore
- Archives of physical medicine and rehabilitation
- 1 May 2013
The ability of this population with chronic disease to increase 6MWD and daily step count with a WB exercise program compared with an NWB exercise program is indicated. Expand
Lower Physical Activity Is Associated With Higher Intermuscular Adipose Tissue in People With Type 2 Diabetes and Peripheral Neuropathy
It is found that people with diabetes and peripheral neuropathy and without severe foot deformity appear to be able to take a large number of steps per day. Expand
Adipose tissue content, muscle performance and physical function in obese adults with type 2 diabetes mellitus and peripheral neuropathy.
- Daniel C Bittel, A. Bittel, +5 authors D. Sinacore
- Journal of diabetes and its complications
- 1 March 2015
T2DMPN may represent a shift in adipose tissue accumulation from SQAT to IMAT depots, which is inversely associated with muscle performance and physical function in obese adults with and without type 2 diabetes and peripheral neuropathy. Expand
Magnetic resonance imaging measurement reproducibility for calf muscle and adipose tissue volume
- P. Commean, L. Tuttle, M. Hastings, M. Strube, Michael J. Mueller
- Journal of magnetic resonance imaging : JMRI
- 1 December 2011
A new semiautomated method for segmenting and measuring the volume of the muscle, bone, and adipose tissue in calf muscle compartments using magnetic resonance images is described and the intrarater and interrater reproducibility of the measures is determined. Expand
Comparison of pelvic muscle architecture between humans and commonly used laboratory species
Rat best approximates the human PFM, followed by mouse in terms of muscle design among commonly used laboratory animals, and negative allometric scaling of PFM architectural parameters is likely due to the multifaceted function of these muscles. Expand
Post-mortem timing of skeletal muscle biochemical and mechanical degradation.
Passive mechanics, myosin heavy chain, and collagen content were all unaffected while the titin protein degraded up to 80% over 7 days post-mortem, indicating that fresh cadaveric tissue may be used for passive mechanical testing and that certain biochemical properties are unchanged up to 7 days after death. Expand