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Epigenetic regulation of airway inflammation.
Diverse cellular functions including the regulation of inflammatory gene expression, DNA repair and cell proliferation are regulated by epigenetic changes. Transcriptional co-activators possessExpand
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Suppression of lipopolysaccharide‐ and tumour necrosis factor‐α‐induced interleukin (IL)‐8 expression by glucocorticoids involves changes in IL‐8 promoter acetylation
There is accumulating evidence that the transrepressional effect of glucocorticoids in down‐regulating proinflammatory gene expression might be regulated by an action on histone acetylation. ToExpand
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Triamcinolone Acetonide and Dexamethasome Suppress TNF‐α‐Induced Histone H4 Acetylation on Lysine Residues 8 and 12 in Mononuclear Cells
!" #! # ! $ % &' ' ! ' ($ ) * ! $& ! ! $'! #+ ! #! $$ #! !" % $ ' , $ $ $ $ ' + ( $ ( ' ! ' # $ ( &' $ $ . % " .! ## ( ! & ( ' ! ' #! ' # ' # $ ( . ' # $ ' &! ' ! $ $/ 0 1 2 ( 23 &! % (&' % ! $'! # (Expand
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Differential patterns of histone acetylation in inflammatory bowel diseases
Post-translational modifications of histones, particularly acetylation, are associated with the regulation of inflammatory gene expression. We used two animal models of inflammation of the bowel andExpand
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13th European Respiratory Society Annual Congress
The 13th Annual European Respiratory Society congress was held recently (27 September – 1 October, 2003) at the International Conference Centre in Vienna. With over 14,800 delegates this was theExpand
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Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma
ABSTRACT We previously identified dipeptidylpeptidase 10 (DPP10) on chromosome 2 as a human asthma susceptibility gene, through positional cloning. Initial association results were confirmed in manyExpand
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Histone acetylation and inflammatory mediators in inflammatory bowel disease
A thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy of the University of Luton