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New lignan glycosides with potent antiinflammatory effect, isolated from Justicia ciliata.
Two new lignan glycosides were isolated from the whole plant of Justicia ciliata and strongly inhibited the accumulation of NO(2)(-) in lipopolysaccharide-stimulated RAW 264.7 cells in a concentration-dependent manner.
Synthetic chalcones as potential anti-inflammatory and cancer chemopreventive agents.
It is demonstrated that 1-3, and 7 have anti-inflammatory effects and 5, 6, and 12 are potential anti- inflammation and cancer chemopreventive agents.
Structure-activity relationship studies on chalcone derivatives. the potent inhibition of chemical mediators release.
The potent inhibitory effect of 2',5'-dihydroxy- dihydrochaclones on NO production in LPS-activated macrophages and microglial cells is proposed to be useful for the relief of septic shock.
Inhibition of lipopolysaccharide-stimulated NO production by a novel synthetic compound CYL-4d in RAW 264.7 macrophages involving the blockade of MEK4/JNK/AP-1 pathway.
The blockade of NO production by CYL-4d in LPS-stimulated RAW 264.7 cells is attributed mainly to interference in the MEK4-JNK-AP-1 signaling pathway and is not restricted to TLR4 activation and immortalized macrophage-like cells.
Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages.
A new lignan glycoside, 4-O-alpha-L-arabinopyranosyl-(1' "-->2' ')-beta-D-apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens, showing potent cytotoxic effects against a number of cancer cells in vitro.
Synthesis and antiinflammatory evaluation of 9-anilinoacridine and 9-phenoxyacridine derivatives.
The results indicated that the antiinflammatory effects of acridine derivatives were mediated, at least in part, through the suppression of chemical mediators released from mast cells, neutrophils, and macrophages and that these compounds have the potential to be novel antiinflammatory agents with no significant cytotoxicity.
Synthesis and Anti‐inflammatory Effect of Chalcones
Novel series of chalcones, 2′‐hydroxy‐ and 2′,5′‐dihydroxychalcones were synthesized and their inhibitory effects on the activation of mast cells, neutrophils, microglial cells and macrophages were evaluated in‐vitro.
Synthesis and anti-inflammatory evaluation of 4-anilinofuro[2,3-b]quinoline and 4-phenoxyfuro[2,3-b]quinoline derivatives. Part 3.
Results indicated that oxime derivatives are more potent than the respective ketone precursors, and the substituent such as Me at the oxime decreased inhibitory activity (6a > or =6b; 7a> or =7b).
Translocation of protein kinase C isoforms in rat neutrophils.
  • L. Tsao, J. Wang
  • Biology, Medicine
    Biochemical and biophysical research…
  • 19 May 1997
The data indicate that the rat neutrophils contain PKCs of three isoform families and the membrane translocation of cPKC and nPKC was observed in cells in response to PMA as well as to fMLP.
Two phenanthraquinones from Dendrobium moniliforme.
This is the first report of compound 1, which possesses a novel 1,4,5,8-diquinone moiety in the phenanthraquinone skeleton, and which showed potent antiinflammatory effects in vitro.