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Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests.
The present work uses the tripeptidomimetic galnon and displays its presumed pharmacophores on a rigid molecular scaffold and provides an example of a systemically active compound based on a scaffold that mimics protein surfaces.
The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain
The structure, biochemical characterization and initial engineering of the PatG macrocyclase domain of Prochloron sp.
A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway.
These findings serve to further enhance the structural diversity of cyanobactins to include tryptophan-prenylated cyclic peptides.
Changes in 2-fluoro-2-deoxy-D-glucose incorporation, hexokinase activity and lactate production by breast cancer cells responding to treatment with the anti-HER-2 antibody trastuzumab.
Helical folding of alkanes in a self-assembled, cylindrical capsule.
The reversible encapsulation of a series of normal alkane guests in a cylindrical host was studied by NMR methods and the longest alkane accommodated, n-tetradecane, adopts a helical conformation to fit in the cavity, a shape that maximizes CH/pi interactions with the aromatic walls of the receptor.
Synthesis and characterisation of biologically compatible TiO2 nanoparticles
- R. Cheyne, Tim A D Smith, L. Trembleau, A. Mclaughlin
- Chemistry, BiologyNanoscale research letters
- 14 June 2011
It is shown that it is possible to exchange the stearic acid from pre-synthesised fatty acid-coated anatase 5-nm nanoparticles with a range of organic ligands with no change in the size or morphology.
Isolation and synthesis of pulmonarins A and B, acetylcholinesterase inhibitors from the colonial ascidian Synoicum pulmonaria.
Pulmonarins A and B are two new dibrominated marine acetylcholinesterase inhibitors that were isolated and characterized from the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian…
Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants.
- Cristina-Nicoleta Alexandru-Crivac, Christian Umeobika, W. Houssen
- Biology, ChemistryChemical communications
- 26 September 2017
A new cyanobactin macrocyclase is reported that can cyclize longer peptide substrates and those not containing proline/thiazoline and thus allows exploring a wider chemical diversity.
One-pot production of 18F-biotin by conjugation with 18F-FDG for pre-targeted imaging: synthesis and radio-labelling of a PEGylated precursor.
Enzymatic reconstitution and biosynthetic investigation of the bacterial carbazole neocarazostatin A.
Reconstitution of the ring A formation of bacterial neocarazostatin A carbazole metabolite is reported, providing evidence of involvement of two unusual aromatic polyketide proteins that suggest how new enzymatic activities can be recruited to specific pathways to expand biosynthetic capacities.