L. Trembleau

Publications43
h-index17
Citations1,183
Highly Influential Citations22
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Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests.
TLDR
The present work uses the tripeptidomimetic galnon and displays its presumed pharmacophores on a rigid molecular scaffold and provides an example of a systemically active compound based on a scaffold that mimics protein surfaces.
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The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain
TLDR
The structure, biochemical characterization and initial engineering of the PatG macrocyclase domain of Prochloron sp.
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A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway.
TLDR
These findings serve to further enhance the structural diversity of cyanobactins to include tryptophan-prenylated cyclic peptides.
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Changes in 2-fluoro-2-deoxy-D-glucose incorporation, hexokinase activity and lactate production by breast cancer cells responding to treatment with the anti-HER-2 antibody trastuzumab.
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Helical folding of alkanes in a self-assembled, cylindrical capsule.
TLDR
The reversible encapsulation of a series of normal alkane guests in a cylindrical host was studied by NMR methods and the longest alkane accommodated, n-tetradecane, adopts a helical conformation to fit in the cavity, a shape that maximizes CH/pi interactions with the aromatic walls of the receptor.
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Synthesis and characterisation of biologically compatible TiO2 nanoparticles
TLDR
It is shown that it is possible to exchange the stearic acid from pre-synthesised fatty acid-coated anatase 5-nm nanoparticles with a range of organic ligands with no change in the size or morphology.
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Isolation and synthesis of pulmonarins A and B, acetylcholinesterase inhibitors from the colonial ascidian Synoicum pulmonaria.
Pulmonarins A and B are two new dibrominated marine acetylcholinesterase inhibitors that were isolated and characterized from the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian…
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Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants.
TLDR
A new cyanobactin macrocyclase is reported that can cyclize longer peptide substrates and those not containing proline/thiazoline and thus allows exploring a wider chemical diversity.
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One-pot production of 18F-biotin by conjugation with 18F-FDG for pre-targeted imaging: synthesis and radio-labelling of a PEGylated precursor.
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Enzymatic reconstitution and biosynthetic investigation of the bacterial carbazole neocarazostatin A.
  • Yating Liu, L. Su, Yi Yu
  • Biology, Chemistry
    The Journal of organic chemistry
  • 15 November 2019
TLDR
Reconstitution of the ring A formation of bacterial neocarazostatin A carbazole metabolite is reported, providing evidence of involvement of two unusual aromatic polyketide proteins that suggest how new enzymatic activities can be recruited to specific pathways to expand biosynthetic capacities.
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