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TFOS DEWS II Diagnostic Methodology report.
The role of the Tear Film and Ocular Surface Society (TFOS) Dry Eye Workshop (DEWS) II Diagnostic Methodology Subcommittee was 1) to identify tests used to diagnose and monitor dry eye disease (DED),Expand
Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles1[S]
TLDR
This study confers novel insights to the compositional details of the existent tear film model, in particular the disputable amphiphilic lipid sublayer constituents, by demonstrating the presence of cholesteryl sulfate, O-acyl-ω-hydroxyfatty acids, and various sphingolipids and phospholipid in tears. Expand
Meibum Lipid Composition in Asians with Dry Eye Disease
TLDR
A comprehensive lipidome of meibum from individuals of an Asian ethnicity is presented, for the first time, which can potentially offer new insights into the higher prevalence of dysfunctional tear syndrome observed amongst Asian populations. Expand
Screening for meibomian gland disease: its relation to dry eye subtypes and symptoms in a tertiary referral clinic in singapore.
TLDR
In dry eye patients, screening for meibomian gland disease based on anteriorization of Marx's line may predict a decrease in TBUT and difficulty in performing certain visual-function-related activities. Expand
Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome1[S]
TLDR
The structurally-specific aberrations in tear lipids reported here were found in patients with or without aqueous deficiency, suggesting a common pathology for both DES subtypes. Expand
Effects of Punctal Occlusion on Clinical Signs and Symptoms and on Tear Cytokine Levels in Patients with Dry Eye.
TLDR
Punctal plug occlusion provided symptomatic relief and reduced fluorescein staining in all except the inferior zone, suggesting a need for earlier treatment with anti-inflammatory agents for management of dry eye disease. Expand
Application of Intrinsic Time-Scale Decomposition (ITD) to EEG signals for Automated seizure Prediction
TLDR
This work automatically classified normal, interictal and ictal EEG signals using the features derived from the ITD representation, and the developed system is clinically ready for mass screening in resource constrained and emerging economy scenarios. Expand
Detection of meibomian glands and classification of meibography images.
TLDR
The user-free computational method is fast, does not suffer from inter-observer variability, and can be useful in clinical studies where large number of images needs to be analyzed efficiently. Expand
Lipid-Containing Lubricants for Dry Eye: A Systematic Review
TLDR
Most studies have demonstrated the effectiveness of LCLs on improving select signs of dry eye, and based on the overall substantial level of evidence, this type of eyedrop can be recommended for use in clinical practice where the aim is to reduce the signs and symptoms of dryEye. Expand
Intra-observer and inter-observer repeatability of ocular surface interferometer in measuring lipid layer thickness
TLDR
The repeatability of measurements being known, the significance of LLT changes measured by this interferometer may be better interpreted and in this small Asian study, the LLT was lower than previously reported studies. Expand
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