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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
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MicroRNA‐7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3‐kinase/Akt pathway in hepatocellular carcinoma
TLDR
Findings indicate that miR‐7 functions as a tumor suppressor and plays a substantial role in inhibiting the tumorigenesis and reversing the metastasis of HCC through the PI3K/Akt/mTOR‐signaling pathway in vitro and in vivo.
View on Wiley
Sustained Activation of JNK/p38 MAPK Pathways in Response to Cisplatin Leads to Fas Ligand Induction and Cell Death in Ovarian Carcinoma Cells*
TLDR
The JNK > c-Jun > Fas L > FasL > Fas pathway plays an important role in mediating cisplatin-induced apoptosis in ovarian cancer cells, and the duration of JNK activation is critical in determining whether cells survive or undergo apoptosis.
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Genome-wide identification and characterization of ATP-binding cassette transporters in the silkworm, Bombyx mori
TLDR
A genome-wide analysis of the silkworm ABC transporters provides an overview of this vital gene superfamily in insects and lays a foundation for future analysis of their physiological function and hormonal regulation.
View on Springer
Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine
TLDR
It is shown that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice.
View on Nature
Inhibition of Tumor Growth with a Vaccine Based on Xenogeneic Homologous Fibroblast Growth Factor Receptor-1 in Mice*
TLDR
It is shown here that vaccination with Xenopus FGFR-1 (pxFR1) is effective at antitumor immunity in three murine models, and may provide a new vaccine strategy for cancer therapy through the induction of autoimmunity against FG FR-1 associated with angiogenesis in a cross-reaction.
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Genome-wide regulation of innate immunity by juvenile hormone and 20-hydroxyecdysone in the Bombyx fat body
TLDR
It is demonstrated that JH acts as an immune-activator while 20E inhibits innate immunity in the fat body during Bombyx postembryonic development.
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20-hydroxyecdysone upregulates Atg genes to induce autophagy in the Bombyx fat body
TLDR
It is concluded that in addition to blocking TORC1 activity for autophagosome initiation, 20E upregulates Atg genes to induce autophagy in the Bombyx fat body.
View on Taylor & Francis
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
TLDR
A set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes are presented.
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Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.
TLDR
Evidence is provided that mTOR signaling phosphoproteins, including mTOR, eukaryotic initiation factor 4E-binding protein-1, p70S6K, and ribosomal protein S6, are highly phosphorylated in AlK+ ALCL cell lines and tumors and that inhibition of mTOR represents a potential therapeutic strategy in ALK+ AlCL.
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