L. Thrun

Publications23
h-index18
Citations1,046
Highly Influential Citations16
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Involvement of thyroid hormones in seasonal reproduction.
This article reviews experiments performed to investigate the importance of thyroid hormones to the expression of the seasonal reproductive cycle of ewes. Thyroidectomy was found to block the… Expand
  • 102
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Thyroid Hormones Act Primarily within the Brain to Promote the Seasonal Inhibition of Luteinizing Hormone Secretion in the Ewe.
In the ewe, thyroid hormones are required for the seasonal suppression of GnRH and LH secretion, thereby maintaining an annual rhythm in reproductive activity. The primary site of action of thyroid… Expand
  • 56
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Thyroxine is permissive to seasonal transitions in reproductive neuroendocrine activity in the ewe.
The observation that circulating thyroxine concentration increases during the breeding season of the ewe, coupled with the finding that thyroid hormones are required for the transition from the… Expand
  • 64
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Mammalian SNM1 is required for genome stability.
The protein encoded by SNM1 in Saccharomyces cerevisiae has been shown to act specifically in DNA interstrand crosslinks (ICL) repair. There are five mammalian homologs of SNM1, including Artemis,… Expand
  • 28
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Endotoxin Inhibits the Reproductive Neuroendocrine Axis While Stimulating Adrenal Steroids: A Simultaneous View from Hypophyseal Portal and Peripheral Blood.
This study was designed to test the hypothesis that systemic immune challenge with endotoxin inhibits the reproductive axis centrally by suppressing GnRH pulsatile release into hypophyseal portal… Expand
  • 112
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Estradiol requirements for induction and maintenance of the gonadotropin-releasing hormone surge: implications for neuroendocrine processing of the estradiol signal.
Two experiments were performed to examine the temporal requirements of the estradiol signal for the GnRH and LH surges in the ewe. Hypophyseal portal and jugular blood (to measure GnRH and LH,… Expand
  • 101
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A critical period for thyroid hormone action on seasonal changes in reproductive neuroendocrine function in the ewe.
Thyroid hormones are obligatory for the annually recurring termination of reproductive activity in a spectrum of seasonal breeders, including sheep. Previous studies involving thyroidectomy and T4… Expand
  • 65
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Systemic challenge with endotoxin stimulates corticotropin-releasing hormone and arginine vasopressin secretion into hypophyseal portal blood: coincidence with gonadotropin-releasing hormone…
We tested the hypothesis that systemic immune/inflammatory challenge (endotoxin) activates the neuroendocrine stress axis centrally by stimulating the secretion of CRH and arginine vasopressin (AVP)… Expand
  • 34
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Endotoxin inhibits the reproductive neuroendocrine axis while stimulating adrenal steroids: a simultaneous view from hypophyseal portal and peripheral blood.
This study was designed to test the hypothesis that systemic immune challenge with endotoxin inhibits the reproductive axis centrally by suppressing GnRH pulsatile release into hypophyseal portal… Expand
  • 24
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Antibiotic Resistance Genes Detection in Environmental Samples
Our aim is to provide an authentic research experience for undergraduate students in a variety of biology courses through collaboration between a four-year university and a community college. This… Expand
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