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Serotonin and fluoxetine modulate bone cell function in vitro
TLDR
Serotonin increased osteoprotegerin (OPG) and decreased receptor activator of NF‐κB ligand (RANKL) secretion from osteoblasts, suggesting a role in osteoblast‐induced inhibition of osteoclast differentiation, whereas fluoxetine had the opposite effect.
Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)α agonist fenofibrate and the PPARγ agonist pioglitazone
TLDR
O resulted in significantly higher femoral BMD and lower medullary area, while PIO induced bone loss and impairment of the mechanical strength, showing opposite skeletal effects of PPARα and γ agonists in intact female rats.
Selective inhibitors of cytosolic or secretory phospholipase A2 block TNF-induced activation of transcription factor nuclear factor-kappa B and expression of ICAM-1.
TLDR
The results indicate that both cPLA2 and sPLA2 may be involved in the TNF signal transduction pathway leading to nuclear translocation of NF-kappaB and to NF- kappaB-activated gene expression in HaCaT cells.
Identification of serum microRNA profiles in colon cancer
TLDR
Serum miRNA expression profiling may be utilised in early detection of colon cancer by correctly assigned stage I–II colon cancer patients based on miRNA profiles of stage IV patients.
Expression and regulation of resistin in osteoblasts and osteoclasts indicate a role in bone metabolism
TLDR
Recombinant resistin increased the number of differentiated osteoclasts and stimulated NFκB promoter activity, indicating a role in osteoclastogenesis.
TFcheckpoint: a curated compendium of specific DNA-binding RNA polymerase II transcription factors
TLDR
This work compiled the list of all putative TFs from nine different resources, ignored factors such as general TFs, mediator complexes and chromatin modifiers, and for the remaining factors checked the available literature for references that support their function as a true sequence-specific DNA-binding RNA polymerase II TF (DbTF).
Distinct differences between TNF receptor 1- and TNF receptor 2-mediated activation of NFkappaB.
TLDR
The results imply that TNFR2 signaling involved in NFkappaB activation proceeds independently of these inhibitor-sensitive signaling components, indicating distinct signaling pathways not shared with TNFR1.
Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling
TLDR
A dynamical model representing a cell fate decision network in the AGS gastric cancer cell line is developed, demonstrating that a model predictive of combinatorial drug effects can be inferred from background knowledge on unperturbed and proliferating cancer cells.
Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells
TLDR
Investigation of gene expression in human carcinoid BON cells after exposure to gastrin, hepatocyte growth factor (HGF), pituitary adenylate cyclase-activating polypeptide or epidermal growth factor identified 12 genes that were regulated by all four factors, indicating that they may be universally regulated during NE GI tumour cell proliferation.
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