• Publications
  • Influence
A tutorial on pilot studies: the what, why and how
Pilot studies for phase III trials - which are comparative randomized trials designed to provide preliminary evidence on the clinical efficacy of a drug or intervention - are routinely performed inExpand
  • 1,677
  • 95
  • PDF
Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis.
CONTEXT Adherence to antiretroviral therapy is a powerful predictor of survival for individuals living with human immunodeficiency virus (HIV) and AIDS. Concerns about incomplete adherence amongExpand
  • 893
  • 50
Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled
CONTEXT Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsedExpand
  • 1,101
  • 38
  • PDF
CONSORT 2010 statement: extension to randomised pilot and feasibility trials
The Consolidated Standards of Reporting Trials (CONSORT) statement is a guideline designed to improve the transparency and quality of the reporting of randomised controlled trials (RCTs). In thisExpand
  • 715
  • 27
  • PDF
Defining Feasibility and Pilot Studies in Preparation for Randomised Controlled Trials: Development of a Conceptual Framework
We describe a framework for defining pilot and feasibility studies focusing on studies conducted in preparation for a randomised controlled trial. To develop the framework, we undertook a DelphiExpand
  • 376
  • 26
  • PDF
Randomized trial of primary PCI with or without routine manual thrombectomy.
BACKGROUND During primary percutaneous coronary intervention (PCI), manual thrombectomy may reduce distal embolization and thus improve microvascular perfusion. Small trials have suggested thatExpand
  • 412
  • 25
  • PDF
Individualized electronic decision support and reminders to improve diabetes care in the community: COMPETE II randomized trial
Background: Diabetes mellitus is a complex disease with serious complications. Electronic decision support, providing information that is shared and discussed by both patient and physician,Expand
  • 198
  • 22
  • PDF
Adherence to Antiretroviral Therapy in Sub-Saharan Africa and North America
Montessori et al,52 2000 0.57 (0.54-0.60) Robertson et al,51 2006 0.68 (0.50-0.82) Temoshok and Wald,5
  • 131
  • 21
Myocardial Injury after Noncardiac Surgery: A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes
Background:Myocardial injury after noncardiac surgery (MINS) was defined as prognostically relevant myocardial injury due to ischemia that occurs during or within 30 days after noncardiac surgery.Expand
  • 448
  • 18
  • PDF
Systematic review of long-term weight loss studies in obese adults: clinical significance and applicability to clinical practice
BACKGROUND:Obesity is a common health problem that requires a long-term care approach. We systematically reviewed long-term (≥2 y) studies investigating dietary/lifestyle, pharmacologic, and surgicalExpand
  • 560
  • 18