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The biology of NKT cells.
TLDR
NKT cell biology has emerged as a new field of research at the frontier between innate and adaptive immunity, providing a powerful model to study fundamental aspects of the cell and structural biology of glycolipid trafficking, processing, and recognition.
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
TLDR
Evidence is reported for microbial, antigen-specific activation of NKT cells against Gram-negative, lipopolysaccharide (LPS)-negative alpha-Proteobacteria such as Ehrlichia muris and Sphingomonas capsulata and shows that glycosylceramides are an alternative to LPS for innate recognition of the Gram- negative, LPS-negative bacterial cell wall.
Interleukin-10 determines viral clearance or persistence in vivo
TLDR
It is shown that persistent viral infection in mice results in a significant upregulation of interleukin (IL)-10 by antigen-presenting cells, leading to impaired T-cell responses, and that a therapy to neutralize IL-10 results in T- cell recovery and the prevention of viral persistence.
An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex
TLDR
The x-ray structure of the complete extracellular fragment of a glycosylated αβ TCR was determined, and its orientation bound to a class I MHC-peptide (pMHC) complex was elucidated from crystals of the TCR- pMHC complex.
Lysosomal Glycosphingolipid Recognition by NKT Cells
TLDR
It is suggested that expression of iGb3 in peripheral tissues may be involved in controlling NKT cell responses to infections and malignancy and in autoimmunity.
In Vivo Identification of Glycolipid Antigen–Specific T Cells Using Fluorescent Cd1d Tetramers
TLDR
The generation and use of mouse CD1d1–glycolipid tetramers are reported, for the first time, to accurately describe, based on TCR specificity, the entire population of NKT cells in vivo and to identify a previously unrecognized population of NK1.1-negative “NKT” cells.
Distinct Functional Lineages of Human Vα24 Natural Killer T Cells
TLDR
It is reported here that CD4+ and CD4−CD8− (double negative [DN]) NKT cell subsets represent functionally distinct lineages with marked differences in their profile of cytokine secretion and pattern of expression of chemokine receptors, integrins, and NK receptors.
Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory
TLDR
The results indicate that CD4+ T-cell memory might become limiting under physiological conditions and that conditions precipitating CD4-cell loss might compromise protective immunity even in the presence of unimpaired CD8+ T thecell responses.
Structural basis of T cell recognition.
TLDR
It is suggested that the knowledge gap between the three-dimensional structure and the signaling function of the TCR can be bridged through a synthesis of molecular biological and biophysical techniques.
A Thymic Precursor to the NK T Cell Lineage
TLDR
Interestingly, cytokine analysis of the developmental intermediates between NK− and NK+ stages showed a T helper cell TH2 to TH1 conversion, suggesting that the regulatory functions of NK T cells may be developmentally controlled.
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