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Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence
TLDR
It is concluded that there is no convincing evidence for praziquantel‐resistant S. mansoni in Senegal, and that the low cure rates can be attributed to high initial worm loads and intense transmission in this area. Expand
Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic
TLDR
A minimum FECR rate of 95% for A. lumbricoides, 70% for hookworm, and 50% for T. trichiura is expected in MEB-dependent PC programs, which may indicate the development of potential drug resistance. Expand
Schistosomiasis control: keep taking the tablets.
TLDR
There is a need for monitoring the spectrum of praziquantel sensitivity of schistosome populations and for an improved knowledge of the precise targets for the action of the drug. Expand
Urogenital schistosomiasis and soil-transmitted helminthiasis (STH) in Cameroon: An epidemiological update at Barombi Mbo and Barombi Kotto crater lakes assessing prospects for intensified control
TLDR
STH is currently at very low levels while urogenital schistosomiasis is of greatest concern at Barombi Kotto, and this assessment highlights a unique opportunity for further study of the epidemiological dynamics at these crater lakes. Expand
A centenary of Robert T. Leiper's lasting legacy on schistosomiasis and a COUNTDOWN on control of neglected tropical diseases
TLDR
Looking to WHO 2020 targets for neglected tropical diseases, COUNTDOWN, an implementation research consortium funded by DFID, UK, which fosters the scale-up of interventions and confirm the current relevance of Leiper's original research is introduced. Expand
The molecular speciation of soil-transmitted helminth eggs collected from school children across six endemic countries.
TLDR
The study indicates that STH infections in humans are predominantly caused by human STH species and suggests that zoonotic transmission occurs on a local scale. Expand
Towards interruption of schistosomiasis transmission in sub-Saharan Africa: developing an appropriate environmental surveillance framework to guide and to support ‘end game’ interventions
TLDR
How strategies need to be adapted and tailored to the local level to better guide and support future interventions through this transition from morbidity- to transmission-focused interventions is discussed. Expand
Population genetic structure of Schistosoma bovis in Cameroon
TLDR
This study provides novel insights into genetic diversity and population genetic structure of S. bovis, a highly widespread and prevalent schistosome infecting ruminants and therefore of veterinary importance. Expand
A pilot study using wearable global positioning system data loggers to compare water contact levels: Schistosoma haematobium infection in pre-school-age children (PSAC) and their mothers at Barombi
TLDR
This study shows the potential of GPS data loggers to clarify the at-risk status of PSAC and mothers and demonstrates similar water contact levels between the child and mother groups, although certain individuals were numerical outliers. Expand
Identifying thresholds for classifying moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR
The World Health Organization (WHO) has defined moderate-to-heavy intensity (M&HI) infections with soil-transmitted helminths (Ascaris lumbricoides, Trichuris trichiura and the two hookworms,Expand
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