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Metabolic effects of fructose and the worldwide increase in obesity.
Although there is compelling evidence that very high fructose intake can have deleterious metabolic effects in humans as in rodents, the role of fructose in the development of the current epidemic of metabolic disorders remains controversial.
Regulation of body weight in humans.
Present evidences suggest that genetic and environmental factors influence eating behavior of people prone to obesity and that diets that are high in fat or energy dense undermine body weight regulation by promoting an overconsumption of energy relative to need.
Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans.
- P. Vollenweider, L. Tappy, U. Scherrer
- Biology, MedicineThe Journal of clinical investigation
- 1 July 1993
It is suggested that in humans hyperinsulinemia per se, rather than insulin-induced stimulation of carbohydrate metabolism, is the main mechanism that triggers both sympathetic activation and vasodilation in skeletal muscle.
Metabolic effects of fructose
Consuming large amounts of fructose can lead to the development of a complete metabolic syndrome in rodents and in humans, fructose consumed in moderate to high quantities in the diet increases plasma triglycerides and alters hepatic glucose homeostasis, but does not appear to cause muscle insulin resistance or high blood pressure in the short term.
Fructose and metabolic diseases: new findings, new questions.
Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men.
In conclusion, high-fructose diet induced dyslipidemia and hepatic and adipose tissue insulin resistance and fish oil reversed dys Lipidemia but not insulin resistance.
Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans.
- P. Vollenweider, D. Randin, L. Tappy, E. Jéquier, P. Nicod, U. Scherrer
- Medicine, BiologyThe Journal of clinical investigation
- 1 June 1994
It is concluded that insulin resistance in obese subjects is associated with increased fasting MSNA and a specific impairment of sympathetic neural responsiveness to physiological hyperinsulinemia in skeletal muscle tissue.
Effect of a Thermogenic Beverage on 24‐Hour Energy Metabolism in Humans
Testing whether consumption of a beverage containing active ingredients will increase 24‐hour energy metabolism in healthy, young, lean individuals finds it to be a good idea.
A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans.
Moderate fructose supplementation over 4 wk increases plasma triacylglycerol and glucose concentrations without causing ectopic lipid deposition or insulin resistance in healthy humans.
Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes.
A 7-d high-fructose diet increased ectopic lipid deposition in liver and muscle and fasting VLDL-triacylglycerols and decreased hepatic insulin sensitivity in healthy offspring of patients with type 2 diabetes, suggesting that these individuals may be more prone to developing dyslipidemia when challenged by high fructose intakes.