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Overexpression of EPS8L3 promotes cell proliferation by inhibiting the transactivity of FOXO1 in HCC.
TLDR
Experiments illustrated that overexpressing EPS8L3 promotes the expression of p-AKT, Cyclin D1, but inhibits the transcriptional activity of FOXO1, and suggested that EPS8l3 may be a novel therapeutic target for HCC.
Joint effects between urinary selenium and polymorphisms in methylation related genes on breast cancer risk.
TLDR
It is suggested that selenium was associated with a decreased risk of breast cancer and this beneficial effect was limited to women with CC genotype of MTHFR rs1801133.
HSPA4 Knockdown Retarded Progression and Development of Colorectal Cancer
TLDR
HSPA4 represents a novel prognostic indicator as well as a promising therapeutic target in CRC, further showing that HSPA4 contributes to CRC tumorigenesis through effects on proliferation, migration and survival.
LncRNA RUSC1-AS1 contributes to the progression of hepatocellular carcinoma cells by modulating miR-340-5p/CREB1 axis.
TLDR
It is demonstrated that lncRNA RUSC1-AS1 influenced HCC cell progression by modulating its downstream target miR-340-5p/CREB1 axis via the PI3K/AKT signaling pathway, which may be a potential prognostic and therapeutic target for treating HCC.
Mortalin/glucose-regulated protein 75 promotes the cisplatin-resistance of gastric cancer via regulating anti-oxidation/apoptosis and metabolic reprogramming
TLDR
It is indicated that GRP75 was involved in the cisplatin-resistance of GC and thatGRP75 could be a potential therapeutic target for restoring the drug response in platinum- Resistance cells and a useful additive prognostic tool in guiding clinical management of GC patients.
Vitamin D Suppresses Hepatic Stellate Cell Activation by Negatively Regulating Glutamine/β-Catenin Metabolism
TLDR
Vitamin D suppressed HSC activation and alleviated mouse liver fibrosis by inhibiting the Gln/β-catenin metabolism.