Share This Author
Stem cells of the adult cornea: From cytometric markers to therapeutic applications
- L. Takács, E. Tóth, A. Berta, G. Vereb
- Biology, MedicineCytometry. Part A : the journal of the…
- 1 January 2009
This review summarizes the current state of knowledge on corneal epithelial, stromal and endothelial stem cells and places special emphasis on the molecular markers that may help to identify these cells, and the recently revealed mechanisms that could maintain their “stemness” or drive their differentiation.
Cyclin-dependent Kinase 5 Regulates Endothelial Cell Migration and Angiogenesis
- J. Liebl, Sabine B. Weitensteiner, S. Zahler
- BiologyThe Journal of Biological Chemistry
- 7 September 2010
It is shown that cyclin-dependent kinase 5 (Cdk5), an important modulator of neuronal processes, regulates endothelial cell migration and angiogenesis, suggesting Cdk5 as a novel target for antiangiogenic therapy.
Transforming growth factor-beta induced protein, betaIG-H3, is present in degraded form and altered localization in lattice corneal dystrophy type I.
Comparison of electrophoretic profiles of normal and dystrophic corneas revealed a 42 kD protein, which was present only in Dystrophic Corneas, which may reflect the role of betaIG-H3 in extracellular matrix construction and/or amyloid formation.
Expression of betaig-h3 is lower than normal in keratoconus corneas but increases with scarring.
The localization of betaig-h3, a recently described extracellular matrix protein in keratoconus corneas is examined both in the absence and presence of subepithelial scarring to suggest paucity of Betaig-H3 in the corneal stroma may lead to decreased mechanical stability and contribute to the development of keratconus.
Myopia and Late-Onset Progressive Cone Dystrophy Associate to LVAVA/MVAVA Exon 3 Interchange Haplotypes of Opsin Genes on Chromosome X.
- O. Orosz, I. Rajta, G. Losonczy
- Biology, MedicineInvestigative ophthalmology & visual science
- 1 March 2017
It is shown that LVAVA haplotype of the OPN1LW gene and MVAVA chromosomes cause apparently nonsyndromic high myopia in young patients but lead to progressive cone-rod dystrophy with deuteranopia and protanopia in middle-aged patients corresponding to a previously unknown disease course.
Trombophilic screening for nonarteritic anterior ischemic optic neuropathy
- V. Nagy, Z. Steiber, G. Pfliegler
- Medicine, BiologyGraefe's Archive for Clinical and Experimental…
Based on the results it appears that thrombophilia is likely to contribute to the development of NAION besides vascular damage due to the presence of cardiovascular risk factors.
Immunohistochemical detection of βIG-H3 in scarring human corneas
- L. Takács, A. Csutak, E. Balázs, A. Berta
- MedicineGraefe's Archive for Clinical and Experimental…
- 9 June 1999
The results prove the presence of increased amounts of βIG-H3 at the sites of scarring in human corneas, irrespective of the pathological process leading to scar formation.
Segregation analysis suggests that keratoconus is a complex non‐mendelian disease
Complex segregation analysis of 60 unrelated sporadic keratoconus (KC) families was performed to reveal the presumed mode of inheritance in our dataset.
Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases
This study provides first information on how to modify roscovitine to develop Cdk inhibitors with increased antiangiogenic activity and suggests the application of existing and the development of new Cdk inhibitor to inhibit both, cancer cell proliferation and angiogenesis.
TGFBI (BIGH3) gene mutations in Hungary--report of the novel F547S mutation associated with polymorphic corneal amyloidosis.
It is concluded that molecular genetic analysis is required to confirm the diagnosis of corneal dystrophies and the first cases of Avellino dystrophy from Central-Eastern Europe are reported.