Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae).
- G. Pettit, M. Hoard, J. Chapuis
- BiologyJournal of Ethnopharmacology
- 1 August 1996
Isolation and Structure of Halistatin 1 from the Eastern Indian Ocean Marine Sponge Phakellia carteri
- G. Pettit, R. Tan, L. Tackett
- Chemistry, Biology
- 1 April 1993
A highly potent new polyether macrolide antimitotic agent designated halistatin 1 was isolated from Phakellia carteri and caused the accumulation of cells arrested in mitosis, inhibited tubulin polymerization, and inhibited the binding of radiolabeled vinblastine and GTP to tubulin.
Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives).
- G. Pettit, Y. Meng, L. Tackett
- ChemistryJournal of Natural Products
- 1 February 2004
Evaluation against the murine P388 lymphocytic leukemia cell line and human tumor cell lines showed podophyllotoxin derivatives 2 and 3 to be strong cancer cell line growth inhibitors and substances 4, 5, 8, and 15 to have marginal cancer cell Line inhibitory activities.
Antineoplastic agents. 520. Isolation and structure of irciniastatins A and B from the Indo-Pacific marine sponge Ircinia ramosa.
- G. Pettit, Junyao Xu, Jean M. Schmidt
- ChemistryJournal of Medicinal Chemistry
- 30 January 2004
Structural elucidation by a combination of spectral analyses, primarily high resolution mass and 2D-NMR spectroscopy, revealed the unusual structures 1 and 2 in Ircinia ramosa.
Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from Phakellia sp.
Two new marine sponge constituents, phakellistatin 10 and 11, were found to be cyclic octapeptides that significantly inhibited growth of the murine P-388 lymphocytic leukemia and human cancer cell lines.
Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,).
- G. Pettit, F. Hogan, Felicia M. Craciunescu
- BiologyJournal of Natural Products
- 8 March 2008
The isolation of interesting and valuable cancer cell growth inhibitors including majusculamide C, axinastatin 5, bengazoles A, B, and E, manzamine A, jaspamide, and neoechinulin A has been summarized.
Antineoplastic agents. 168. Isolation and structure of axinohydantoin
- G. Pettit, C. L. Herald, F. Camou
- Biology
- 1990
Present experience with sponges in the Axinella and Hymeniacidon genera suggests that the previously known hymenialdisine and analogous imidazole derivatives may be widely distributed among these and related orange colored Porifera.
Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp.
- G. Pettit, S. Ducki, Michael D. Williams
- Chemistry, BiologyJournal of Natural Products
- 2002
A new cancer cell growth inhibitor designated pedilstatin was found to significantly inhibit growth of the P388 lymphocytic leukemia cell line with an ED(50) of 0.28 microg/mL and to afford protection of human-derived lymphoblastoid CEM-SS cells from infection and cell-killing by HIV-1.
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