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Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin.
Xanthine oxidase inhibitors are known to be therapeutically useful for the treatment of hepatitis and brain tumor. Baicalein, baicalin and wogonin, isolated from Scutellaria rivularis, have beenExpand
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Construction of tissue-engineered composite intervertebral disc and preliminary morphological and biochemical evaluation.
The aim of this study was to construct tissue-engineered composite intervertebral disc (IVD) consisting of demineralized bone matrix gelatin (DBMG) and collagen II/hyaluronate/chondroitin-6-sulfateExpand
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Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors
Abstract N-Substituted isatin derivatives were prepared from the reaction of isatin and various bromides via two steps.Expand
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Synthesis and biological activities of a novel class of azole-containing antifungal agents
Abstract A series of novel 1,2,3,4-tetrahydroisoquinoline derived azoles has been designed and synthesized as antifungal agents which might function as inhibitors of cytochrome P-450 dependentExpand
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Synthesis and biological evaluation of substituted 6-alkynyl-4-anilinoquinazoline derivatives as potent EGFR inhibitors.
A series of C-6 or C-3' alkynyl-substituted 4-anilinoquinazoline derivatives was prepared straightforwardly by a Sonogashira reaction of the corresponding bromo-substituted 4-anilinoquinazolines.Expand
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Asymmetric syntheses of trans-3,4-disubstituted 2-piperidinones and piperidines
Abstract A convenient and practical method for the preparation of chiral 4-aryl-2-piperidinone from 3-arylglutaric anhydride and (S)-methylbenzylamine is described. Acylation or alkylation at theExpand
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Stereoselective reactions of N-acyl-N,O-acetals with 2-(trimethysilyloxy)furan
Abstract Reactions of acyclic chiral N-acyl-N,O-acetals with 2-(trimethylsilyloxy)furan and BF 3 ·Et 2 O produces 4- (aminoalkyl)-2-buten-4-olides in 30% to 62% yield and variable diastereomericExpand
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Preparation of Acyclic N-Acyl-N,O-acetals by Decarboxylation of N-Protected α-Amino Acids and Studies of Asymmetric Amidoalkylation with Trimethylsilyl Cyanide
Abstract Oxidative decarboxylation of N-acyl-α-amino acids with lead tetra-acetate followed by treatment with methanol provides a facile method for preparation of acyclic N-acyl-N,O-acetals, whichExpand
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Identification of Multiple Constituents in Shuganjieyu Capsule and Rat Plasma after Oral Administration by Ultra-Performance Liquid Chromatography Coupled with Electrospray Ionization and Ion Trap
Shuganjieyu (SGJY) capsule is a classical formula widely used in Chinese clinical application. In this paper, an ultra-performance liquid chromatography coupled with electrospray ionization and ion...
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