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Prognostic utility and characterization of cell-free DNA in patients with severe sepsis
IntroductionAlthough sepsis is the leading cause of death in noncoronary critically ill patients, identification of patients at high risk of death remains a challenge. In this study, we examined theExpand
Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms
Objective— Activation of neutrophils by microbial or inflammatory stimuli results in the release of neutrophil extracellular traps (NETs) that are composed of DNA, histones, and antimicrobialExpand
The role of leukocytes in thrombosis.
In recent years, the traditional view of the hemostatic system as being regulated by a coagulation factor cascade coupled with platelet activation has been increasingly challenged by new evidenceExpand
Breast cancer chemotherapy induces the release of cell‐free DNA, a novel procoagulant stimulus
See also van den Berg YW, Reitsma PH. Not exclusively tissue factor: neutrophil extracellular traps provide another link between chemotherapy and thrombosis. This issue, pp 2311–2.
The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels.
Genetic variation in or near the C-type lectin domain family 4 member M (CLEC4M) has been associated with plasma levels of von Willebrand factor (VWF) in healthy individuals. CLEC4M is a lectinExpand
Effects of the chemotherapeutic agent doxorubicin on the protein C anticoagulant pathway
Although chemotherapy treatment is associated with an increased risk of thrombosis, the pathogenic mechanisms for the thrombogenic effect of chemotherapeutic drugs are poorly understood. WeExpand
Kaiso regulates Znf131-mediated transcriptional activation.
Kaiso is a dual-specificity POZ-ZF transcription factor that regulates gene expression by binding to sequence-specific Kaiso binding sites (KBS) or methyl-CpG dinucleotide pairs. Kaiso was firstExpand
Chemotherapeutic agents doxorubicin and epirubicin induce a procoagulant phenotype on endothelial cells and blood monocytes
Summary.  Background: Although chemotherapy is associated with an increased risk of thrombosis, the pathogenic mechanisms by which chemotherapeutic agents exert prothrombotic effects are unclear.Expand
Protective effects of activated protein C in sepsis.
Sepsis remains a complex syndrome associated with significant morbidity and mortality. It is now widely accepted that the pathways of inflammation, coagulation, apoptosis, and endothelialExpand
Histones link inflammation and thrombosis through the induction of Weibel–Palade body exocytosis
Essentials Dysregulated DNA and histone release can promote pathological immunothrombosis. Weibel‐Palade bodies (WPBs) are sentinel‐like organelles that respond to proinflammatory stimuli. HistonesExpand
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