• Publications
  • Influence
Early childhood general anaesthesia exposure and neurocognitive development.
  • L. Sun
  • Medicine
  • British journal of anaesthesia
  • 1 December 2010
A great deal of concern has recently arisen regarding the safety of anaesthesia in infants and children. There is mounting and convincing preclinical evidence in rodents and non-human primates thatExpand
Exposure to Environmental Tobacco Smoke and the Risk of Adverse Respiratory Events in Children Receiving General Anesthesia
Background Exposure to environmental tobacco smoke is associated with detrimental effects on pulmonary function in children. The authors investigated the relation between airway complications inExpand
Sympathetic response during cardiopulmonary bypass: mild versus moderate hypothermia.
OBJECTIVE To determine the sympathetic response during cardiopulmonary bypass at mild (34 degrees C) and moderate (28 degrees C) hypothermia. DESIGN A randomized study. SETTING TertiaryExpand
Muscarinic receptor heterogeneity in neonatal rat ventricular myocytes in culture.
Carbachol increased ventricular automaticity in a concentration-dependent fashion from a control rate of 72 +/- 5 (mean +/- SEM) to 86 +/- 4 beats per minute at 10(-4) M carbachol. Pirenzepine, anExpand
Heart rate variability in neonatal rats after perinatal cocaine exposure.
Pregnant rats received saline once daily (Control QD) or twice daily (Control BID), cocaine 2 mg/kg IV daily (COC QD) or twice daily (COC BID) throughout gestation beginning on gestational day 4. TheExpand
Sympathetic neural modulation of cardiac impulse initiation and repolarization in the newborn rat.
We injected neonatal rats with nerve growth factor, the antiserum to nerve growth factor, or placebo for the first 10 days of life. Our goal was to determine the relation between sympatheticExpand
Sympathetic innervation modulates ventricular impulse propagation and repolarisation in the immature rat heart.
OBJECTIVE When cardiac sympathetic innervation in neonatal rats is retarded by antiserum to nerve growth factor, there is a corresponding increase in the QT interval on ECG. Since the propagation ofExpand
Incidence of atrial fibrillation after mild or moderate hypothermic cardiopulmonary bypass
Objectives: Atrial fibrillation remains a significant source of morbidity after coronary artery bypass grafting (CABG). Whether cardiopulmonary bypass (CPB) temperature influences the occurrence ofExpand
Perinatal Cocaine Exposure Impairs Myocardial &bgr;-Adrenoceptor Signaling in the Neonatal Rat
  • L. Sun
  • Medicine
  • Anesthesia and analgesia
  • 1 January 2000
Cardiac dysfunction occurs in infants with prenatal cocaine exposure, and gestational cocaine exposure induces presynaptic and postsynaptic changes in the central monoaminergic receptor pathways. TheExpand
Gender differences in pain sensitivity and responses to analgesia.
  • L. Sun
  • Medicine
  • The journal of gender-specific medicine : JGSM…
  • 1 September 1998
Variations in pain sensitivity between men and women have been reported in numerous studies. Women have more severe and longer lasting pain than men. The goal of this review is to summarize theExpand