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A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus.
The Wnt pathway regulates the early dorsal-ventral axis in Xenopus through a complex of beta-catenin and HMG box transcription factors of the Lef/Tcf family. We show that the promoter of theExpand
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Local Tissue Interactions across the Dorsal Midline of the Forebrain Establish CNS Laterality
The mechanisms that establish behavioral, cognitive, and neuroanatomical asymmetries are poorly understood. In this study, we analyze the events that regulate development of asymmetric nuclei in theExpand
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The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes
Regulation of gene expression by mitogen-activated protein kinases (MAPKs) is essential for proper cell adaptation to extracellular stimuli. Exposure of yeast cells to high osmolarity results inExpand
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Developmental analysis of Lingo‐1/Lern1 protein expression in the mouse brain: Interaction of its intracellular domain with Myt1l
Lingo‐1 (also known as Lern1) is a component of the Nogo receptor complex that mediates intracellular signaling in response to myelin associated inhibitors (MAIs): NogoA, MAG, and Omgp. SignalingExpand
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Expression of the chicken homeobox-containing gene GHox-8 during embryonic chick limb development
Homeobox-containing genes are thought to be involved in the regulation of pattern formation and specification of positional information during vertebrate limb development. Because of itsExpand
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A role for notochord in axial vascular development revealed by analysis of phenotype and the expression of VEGR-2 in zebrafish flh and ntl mutant embryos
The notochord is required for the differentiation of nearby tissues, including the neural tube and the floor plate. Because the dorsal aorta and axial vein are midline structures, their developmentExpand
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The expression pattern of the Distal-less homeo☐-containing gene Dlx-5 in the developing chick limb bud suggests its involvement in apical ectodermal ridge activity, pattern formation, and cartilage
Here we report the isolation from a chick limb bud cDNA library of a cDNA that contains the full coding sequence of chicken Dlx-5, a member of the Distal-less (Dlx) family of homeobox-containingExpand
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Conservation of intracellular Wnt signaling components in dorsal-ventral axis formation in zebrafish
Abstract The mechanism of early dorso-ventral axis specification in zebrafish embryos is not well understood. While β-catenin has been clearly implicated as a determinant of the axis, the factorsExpand
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GHox-7: a chicken homeobox-containing gene expressed in a fashion consistent with a role in patterning events during embryonic chick limb development.
Homeobox-containing (HOX) genes are thought to be involved in the regulation of pattern formation and specification of positional information during vertebrate limb development. We report theExpand
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Identification of a spatially specific enhancer element in the chicken Msx-2 gene that regulates its expression in the apical ectodermal ridge of the developing limb buds of transgenic mice.
Msx-2 is a member of the Msx family of homeobox-containing genes expressed in a variety of embryonic tissues involved in epithelial-mesenchymal interactions and pattern formation. In the developingExpand
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