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Genomewide Association Study of Severe Covid-19 with Respiratory Failure
A 3p21.31 gene cluster is identified as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and a potential involvement of the ABO blood-group system is confirmed. Expand
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus.
The Wnt pathway regulates the early dorsal-ventral axis in Xenopus through a complex of beta-catenin and HMG box transcription factors of the Lef/Tcf family. We show that the promoter of theExpand
Local Tissue Interactions across the Dorsal Midline of the Forebrain Establish CNS Laterality
It is proposed that laterality is determined by a competitive interaction between the left and right epithalamus and that Nodal signaling biases the outcome of this competition. Expand
The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes
Data indicate that targeting of the Rpd3 histone deacetylase to osmoresponsive promoters by the MAPK Hog1 is required to induce gene expression on stress. Expand
A myriad of miRNA variants in control and Huntington’s disease brain regions detected by massively parallel sequencing
The results show that miRNA variability is a ubiquitous phenomenon in the adult human brain, which may influence gene expression in physiological and pathological conditions. Expand
Developmental analysis of Lingo‐1/Lern1 protein expression in the mouse brain: Interaction of its intracellular domain with Myt1l
It is proposed that the intracellular domain of Lingo‐1 contributes to signaling and show that it interacts with the postmitotic neuronal specific zinc finger protein Myt1l, suggesting that Lingo'1 may regulate MyT1l transcription factor activity by affecting its subcellular localization. Expand
A role for notochord in axial vascular development revealed by analysis of phenotype and the expression of VEGR-2 in zebrafish flh and ntl mutant embryos
Differences in the vascular phenotype between the two mutations correlated with the severity of their axial mesodermal defects, and support a role for the notochord in vasculogenesis. Expand
Expression of the chicken homeobox-containing gene GHox-8 during embryonic chick limb development
In situ and dot-blot hybridization analyses have revealed that GHox-8 is expressed in limb bud mesoderm in a temporal and spatial fashion consistent with its involvement in specifying anterior positional identity, which is a member of a family of vertebrate homeobox-containing genes that are highly similar in sequence to the Drosophila msh gene. Expand
Cyclic AMP signaling restricts activation and promotes maturation and antioxidant defenses in astrocytes
It is indicated that cAMP signaling is a key pathway promoting astrocyte maturation and restricting their developmental and activation features, and a positive modulation of cAMP signaled may promote the normal state of differentiated astroglial cells and favor the protection and function of neuronal networks. Expand
The expression pattern of the Distal-less homeo☐-containing gene Dlx-5 in the developing chick limb bud suggests its involvement in apical ectodermal ridge activity, pattern formation, and cartilage
Here we report the isolation from a chick limb bud cDNA library of a cDNA that contains the full coding sequence of chicken Dlx-5, a member of the Distal-less (Dlx) family of homeobox-containingExpand