• Publications
  • Influence
Serotonin‐immunoreactivity in peripheral tissues of the opisthobranch molluscs Pleurobranchaea californica and Tritonia diomedea
TLDR
The distribution of serotonin (5‐HT)‐immunoreactive elements in peripheral organs of the sea‐slugs Pleurobranchaea californica and Tritonia diomedea was studied, suggesting a role for 5‐HT in sensory signaling. Expand
Serotonin immunoreactivity in the central nervous system of the marine molluscs Pleurobranchaea californica and Tritonia diomedea
TLDR
The clustering of 5‐HT‐IR neurons, their diverse axon pathways, and the known physiologic properties of their identified members are consistent with a loosely organized arousal system of serotonergic neurons whose components can be generally or differentially active in expression of diverse behaviors. Expand
Regulation of Labellar and Tarsal Taste Thresholds in the Black Blowfly, Phormia Regina
TLDR
It appears that labellar and tarsal thresholds in the blowfly are similarly affected by consumption of aqueous sucrose, however, inhibitory feedback from the RN, which is partially responsible for elevation of tartsal thresholds after a meal, does not affect labellar thresholds. Expand
cAMP-activated Na+ current of molluscan neurons is resistant to kinase inhibitors and is gated by cAMP in the isolated patch
The cAMP-dependent Na+ current (INa,cAMP) modulates excitability in many molluscan neurons. Rapid activation of INa,cAMP by cyclic nucleotide, its ion dependence, and its blockade by divalent cationsExpand
Cyclic AMP Levels, Adenylyl Cyclase Activity, and Their Stimulation by Serotonin Quantif ied in Intact Neurons
TLDR
Using neurons of the marine opisthobranch snail Pleurobranchaea californica, theory and conventional voltage clamp techniques are applied to use INa,cAMP to report basal levels of endogenous cAMP and adenylyl cyclase, and their stimulation by serotonin, to confirm the functional character of INa-cAMP in the context of high levels of native cAMP. Expand
Cyclic AMP-gated sodium current in neurons of the pedal ganglion of Pleurobranchaea californica is activated by serotonin.
TLDR
The decay rate of the INa,cAMP response is affected by phosphodiesterase inhibitors and can be taken as a sensitive measure of the rate of cAMP degradation, suggesting that 5-HT action is mediated specifically by cAMP. Expand
Nitric oxide potentiates cAMP-gated cation current in feeding neurons of Pleurobranchaea californica independent of cAMP and cGMP signaling pathways.
TLDR
The results suggest that NO acts through a novel mechanism to regulate the gain of cAMP-dependent neuromodulatory pathways that activate I(Na,cAMP) and may thereby affect the set points of feeding network excitability and reactivity to exogenous input. Expand
cAMP, Ca2+, pHi, and NO Regulate H-like Cation Channels That Underlie Feeding and Locomotion in the Predatory Sea Slug Pleurobranchaea californica.
TLDR
An integrated model of the action of cAMP, Ca2+, pHi, and NO in the feeding network postulates that NO regulates proton conductance to cause neuronal excitation in the cell body on the one hand, and relief of activity-induced hyperacidification in fine dendritic processes on the other. Expand
...
1
2
...