L. Steranka

Publications47
h-index20
Citations1,814
Highly Influential Citations24
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Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.
Autoradiographic studies localize [3H]bradykinin receptor binding sites to the substantia gelatinosa, dorsal root, and a subset of small cells in both the dorsal root and trigeminal ganglia of the… Expand
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Antinociceptive effects of bradykinin antagonists.
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Antagonists of B2 bradykinin receptors
Bradykinin and its active metabolites, produced by kallikreins at their sites of action, potently elicit a variety of biological effects: hypotension, bronchoconstriction, gut and uterine… Expand
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Role of serotonergic input in the regulation of the beta-adrenergic receptor-coupled adenylate cyclase system.
The action of desipramine on the norepinephrine-sensitive adenylate cyclase system and the density of beta-adrenergic receptors in rat cortex was studied after selective lesioning of serotonergic… Expand
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Distinct bradykinin receptors mediate stimulation of prostaglandin synthesis by endothelial cells and fibroblasts.
Bradykinin-stimulated prostaglandin synthesis was investigated in Swiss albino 3T3 fibroblasts (Swiss 3T3 cells) and bovine pulmonary artery endothelial cells (CPAE). Previous studies have indicated… Expand
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Species differences in the rate of disappearance of fenfluramine and its effects on brain serotonin neurons.
Abstract A single injection of fenfluramine, the m -trifluoromethyl- N -ethyl derivative of amphetamine, produces long-term decreases in brain levels of 5-hydroxytryptamine (5-HT),… Expand
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Central and peripheral catecholamine depletion by 1-methyl-4-phenyl-tetrahydropyridine (MPTP) in rodents.
1-Methyl-4-phenyl-tetrahydropyridine (MPTP) given in single doses to rats depleted norepinephrine concentration in heart and mesenteric artery but had little effect on catecholamine concentration in… Expand
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Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptors
NPC 168 (naltrexone phenyl oxime) was synthesized as a novel opioid antagonist and evaluated in several in vitro and in vivo assays. NPC 168 inhibited binding to the mu, delta and kappa subtypes of… Expand
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Stereospecific long-term effects of amphetamine on striatal dopamine neurons in rats.
  • L. Steranka
  • Chemistry, Medicine
  • European journal of pharmacology
  • 17 December 1981
Abstract The chronic infusion of amphetamine or a single injection of the drug to iprindole-treated rats produces long-term, possibly neurotoxic, effects on strialal dopamine (DA) neurons.… Expand
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NPC 15669 reduces mortality associated with sepsis in rats.
N-[9H-(2,7-dimethylfluoren-9-ylmethoxy)carbonyl]-L-leucine (NPC 15669), a leukocyte recruitment inhibitor, was investigated for its ability to enhance survival in a rat model of sepsis, fecal… Expand
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