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A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS.
TLDR
An analysis of variation in the distribution of CFU in macroscopic colonies indicates that it might be generated by a well-known probabilistic ("stochastic") process, the "birth-and-death" process. Expand
THE DISTRIBUTION OF COLONY-FORMING CELLS AMONG SPLEEN COLONIES.
Progenitor cells that are recognized by their ability to form colonies of descendants in the spleens of irradiated mice have the capacity for self-renewal. The distribution of new colony-formingExpand
A cytological study of the capacity for differentiation of normal hemopoietic colony‐forming cells
TLDR
Support is provided for the view that colony forming hemopoietic stem cells are multipotent, and that differentiation along more than one pathway can occur during the formation of macroscopic splenic colonies. Expand
Complementation between mutants of CHO cells resistant to a variety of plant lectins
TLDR
Test for complementation, by measuring the lectin-resistant properties of appropriate hybrids, show that seven distinct complementation groups can be delineated among the phenotypically recessive mutants. Expand
Multidrug-resistance phenotype in Chinese hamster ovary cells.
TLDR
These findings are consistent with a molecular mechanism of multidrug resistance whereby the pleiotropic response of the cell is mediated by an overexpression of a cell-surface protein, the P-glycoprotein. Expand
Selection and characterization of eight phenotypically distinct lines of lectin-resistant chinese hamster ovary cells
TLDR
At least 8 different phenotypes have been identified on the basis of this analysis, and complementation between 2 of them has been demonstrated. Expand
Chinese hamster ovary cells selected for resistance to the cytotoxicity of phytohemagglutinin are deficient in a UDP-N-acetylglucosamine--glycoprotein N-acetylglucosaminyltransferase activity.
TLDR
Several clones of Chinese hamster ovary cells resistant to the cytotoxicity of the phytohemagglutinin from Phaseolus vulgaris show decreased binding of 125I-labeled phy tohemag Glucosamine--glycoprotein N-acetylglucosaminyltransferase activity, which apparently results in defective glycosylation of lectin-binding glycoproteins on the cell surface. Expand
Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells
TLDR
Three mechanisms for resistance to methotrexate (Mtx) have been identified in Chinese hamster ovary cells selected for Resistance to this drug and all three classes of resistant cells retain their Mix-resistant phenotype when cultured under nonselectivve conditions. Expand
THE DEVELOPMENT OF VACCINIA VIRUS IN EARLE'S L STRAIN CELLS AS EXAMINED BY ELECTRON MICROSCOPY
TLDR
Experiments in which a very high multiplicity of infection was used revealed that vaccinia is phagocytized by L cells in less than 1 hour after being added to the culture, without any apparent loss of its outer limiting membranes. Expand
The morphogenesis of bacteriophage lambda. IV. Identification of gene products and control of the expression of the morphogenetic information.
TLDR
A kinetic analysis of the amounts of gene products indicated that the synthesis of individual late proteins in phage λ seems to be initiated in an orderly fashion, related to the distance of the genes from the late main promoter between genes Q and S, and indicates the presence of a remarkable control mechanism for gene expression of the left arm. Expand
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