• Publications
  • Influence
A new cyclopyrophosphate as a bacterial antistressor?
In a number of bacteria an unusual glycosyl pyrophosphate was detected when the cells were subjected to oxidative stress, and it is suggested that this compound is the long sought after bacterial antistressor. Expand
Synthesis of a new organic pyrophosphate in large quantities is induced in some bacteria by oxidative stress.
A novel substance that represents greater than 50% of the extractable phosphorus is suggested to play a role as a bacterial antistressor and is thought to be a product of condensation of two molecules of phosphoenolpyruvate whose accumulation is prompted by conversion of intracellular NADPH into an oxidized form. Expand
The ability of bacteria to synthesize a new cyclopyrophosphate correlates with their tolerance to redox-cycling drugs: on a crossroad of chemotherapy, environmental toxicology and immunobiochemical
Many redox-cyclers were recently shown to induce, in some bacterial species, large-scale biosynthesis of a new 2-methylbutan-1,2,3,4-tetraol-2,4-cyclopyrophosphate believed to be involved inExpand
1H NMR urinalysis in glomerulonephritis: a new prognostic criterion.
A new criterion to unmask a group at risk of rapid progression to uremia can be proposed, justifying an early prescription of immune suppressive drugs or other adequate treatment to these patients. Expand
Relationship between intracellular pH and antibiotic biosynthesis in Fusidium coccineum
The study of 31P-NMR spectroscopy in two strains of the fungus Fusidium coccineum suggested that the change in the intracellular pH was responsible for the action of the enzymes in the cells and could be a factor defining the function of the cyanide-resistant respiration pathway and consequently the synthesis of fusidic acid in F. coccinesum. Expand
23Na NMR measurement of the maximal rate of active sodium efflux from human red blood cells
The method for 23Na NMR measurement of the maximal rate of active Na+ efflux from human red blood cells (RBC) is proposed. The nonpenetrating paramagnetic shift reagent (SR)Expand
Bacterial oxidative stress substance spontaneously recyclizes to form 2-methylbutane-1,2,3,4-tetraol-1,2-cyclophospho-4-phosphate.
The cells of Corynebacterium (Brevibacterium) ammonia-genes cultivated in a medium supplemented with diquat or benzylviologen accumulate 2-methylbutane-1,2,3,4-tetraol-2,4- cyclopyrophosphate asExpand
NMR estimation of protective effect of insulin on mouse liver with epinephrine‐induced metabolic lesions
Measurements of cellular phosphates and intracellular pH by 31PNMR, of glycogen by 13C NMR and of lactate by 1H NMR demonstrate the applicability of NMR for evaluating the protective activity of modifiers at various extreme exposures. Expand
Bacteria and pesticides: a new aspect of interaction--involvement of a new biofactor.
Positively charged hydrophobic pesticides of the dipyridyl family [diquat, paraquat, benzylviologen (BV++), etc.] were shown to provoke accumulation of 2-methylbutane-1,2,3,4-tetraol-2,4-Expand
Phosphorus-containing metabolites in anthracycline-resistant murine leukemia P388 cells.
The method of 31P nuclear magnetic resonance was used to study in vivo the level of phosphorus-containing metabolites in P388 leukemia cells sensitive or resistant to rubomycin (daunomycin) and itsExpand