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Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization
MonA exerts cytotoxiс activity by mechanisms different from “classical” apoptosis, and could be a promising new compound to overcome resistance to standard therapies in genitourinary malignancies.
The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus).
The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer
- S. Dyshlovoy, E. Menchinskaya, G. von Amsberg
- Biology, MedicineInternational journal of cancer
- 15 May 2016
The results suggest that FrA is a promising new drug for the treatment of mCRPC, with high efficacy in human prostate cancer cells, while non‐malignant cells were less sensitive to it.
Monanchocidins B-E: polycyclic guanidine alkaloids with potent antileukemic activities from the sponge Monanchora pulchra.
- T. Makarieva, Ksenya M. Tabakmaher, V. Stonik
- Chemistry, BiologyJournal of natural products
- 17 August 2011
Compounds 1-5 show potent cytotoxic activities against HL-60 human leukemia cells with IC50 values of 540, 200, 110, 830, and 650 nM, respectively.
Evaluation of Cancer-Preventive Activity and Structure–Activity Relationships of 3-Demethylubiquinone Q2, Isolated from the Ascidian Aplidium glabrum, and its Synthetic Analogs
Quinones 1 and 3–14 demonstrated cancer-preventive activity in JB6 Cl41 cells, which may be attributed to the induction of p53-independent apoptosis and the length of side chains and on the positions of the methoxyl groups in the quinone part of the molecule.
Aaptamines from the Marine Sponge Aaptos sp. Display Anticancer Activities in Human Cancer Cell Lines and Modulate AP-1-, NF-κB-, and p53-Dependent Transcriptional Activity in Mouse JB6 Cl41 Cells
It is shown that compounds 1–3 demonstrate anticancer activity in THP-1, HeLa, SNU-C4, SK-MEL-28, and MDA-MB-231 human cancer cell lines and all compounds were found to prevent EGF-induced neoplastic transformation of murine JB6 Cl41 cells.
Mycalamide A Shows Cytotoxic Properties and Prevents EGF-Induced Neoplastic Transformation through Inhibition of Nuclear Factors
In murine JB6 Cl41 P+ cells, mycalamide A inhibited epidermal growth factor-induced neoplastic transformation, and induced apoptosis at subnanomolar or nanomolar concentrations, showing promising potential for both cancer-prevention and cytotoxic therapy.
Antileukemic Properties and Structure-Activity Relationships of O- and SGlycosylatedDerivatives of Juglone and Related 1,4-Naphthoquinones
Glycosylated derivatives of physiologically active natural compound juglone and related 1,4- naphthoquinones are known as antifungal, immunomodulatory, and antitumor substances. However, their…
Dactylone inhibits epidermal growth factor-induced transformation and phenotype expression of human cancer cells and induces G1-S arrest and apoptosis.
Application of dactylone and related compounds may lead to decreased malignant cell transformation and/or decreased tumor cell proliferation.
Synaptosides A and A1, triterpene glycosides from the sea cucumber Synapta maculata containing 3-O-methylglucuronic acid and their cytotoxic activity against tumor cells.
Two novel triterpene holostane glycosides, synaptosides A ( 1) and A 1 ( 2), have been isolated from the Vietnamese sea cucumber Synapta maculata (Synaptida, Apodida). Their structures were…