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- Publications
- Influence
Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts.
- S. Hu, L. Shively, +5 authors A. Wu
- Chemistry, Medicine
- Cancer research
- 1 July 1996
A novel engineered antibody fragment (VL-VH-CH3, or "minibody") with bivalent binding to carcinoembryonic antigen (CEA) was produced by genetic fusion of a T84.66 (anti-CEA) single-chain antibody… Expand
Molecular cloning of a gene belonging to the carcinoembryonic antigen gene family and discussion of a domain model.
- J. Thompson, H. Pande, +6 authors J. Shively
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 May 1987
Carcinoembryonic antigen (CEA) is a glycoprotein important as a tumor marker for colonic cancer. Immunological and biochemical studies have shown it to be closely related to a number of other… Expand
Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen.
- Y. Hinoda, M. Neumaier, +6 authors R. Paxton
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 September 1988
We have isolated and sequenced four overlapping cDNA clones from a normal adult human colon library, which together gave the entire nucleotide sequence for biliary glycoprotein I (BGP I). BGP I is a… Expand
Cloning of the genes for T84.66, an antibody that has a high specificity and affinity for carcinoembryonic antigen, and expression of chimeric human/mouse T84.66 genes in myeloma and Chinese hamster…
- M. Neumaier, L. Shively, +5 authors A. Riggs
- Biology, Medicine
- Cancer research
- 1 April 1990
Carcinoembryonic antigen (CEA) is one of the best characterized tumor-associated antigens and is extensively used in the in vitro immunodiagnosis of human colon adenocarcinomas. Among a number of… Expand
Isolation of a cDNA clone for human X-linked 3-phosphoglycerate kinase by use of a mixture of synthetic oligodeoxyribonucleotides as a detection probe.
- J. Singer-Sam, R. Simmer, +5 authors A. Riggs
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 February 1983
We have obtained a cDNA clone encoding most of human X-linked 3-phosphoglycerate kinase (PGK; ATP:3-phospho-D-glycerate 1-phosphotransferase, EC 2.7.2.3). Total mRNA was prepared from human… Expand
Mammalian expression and hollow fiber bioreactor production of recombinant anti-CEA diabody and minibody for clinical applications.
- P. Yazaki, L. Shively, +6 authors A. Wu
- Chemistry, Medicine
- Journal of immunological methods
- 1 July 2001
Genetically engineered radiolabeled antibody fragments have shown great promise for the radioimmunoscintigraphy of cancer. Retaining the exquisite specificity of monoclonal antibodies yet smaller in… Expand
Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen.
- M. Neumaier, W. Zimmermann, L. Shively, Y. Hinoda, A. Riggs, J. Shively
- Biology, Medicine
- The Journal of biological chemistry
- 5 March 1988
NCA (nonspecific cross-reacting antigen), a glycoprotein found in normal lung and spleen, is immunologically related to carcinoembryonic antigen (CEA), which is found in over 95% of colon… Expand
Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase.
- J. Singer-Sam, D. Keith, +5 authors A. Riggs
- Biology, Medicine
- Gene
- 1 December 1984
We have determined the sequence of an 812-bp BamHI-EcoRI restriction fragment containing the 5' region of the human gene for PGK (3-phosphoglycerate kinase or ATP:3-phospho-D-glycerate… Expand
Efficiency in Meter Reading
- L. Shively
- Computer Science
- 1 June 1931
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