Biological studies of post-traumatic stress disorder
This Review attempts to present the current state of understanding of post-traumatic stress disorder on the basis of psychophysiological, structural and functional neuroimaging, and endocrinological, genetic and molecular biological studies in humans and in animal models.
Neurocircuitry Models of Posttraumatic Stress Disorder and Extinction: Human Neuroimaging Research—Past, Present, and Future
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder
The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Additional research will be needed to clarify the exact role of each component of the fear circuitry in the anxiety disorders, determine whether functional abnormalities identified in the Anxiety disorders represent acquired signs of the disorders or vulnerability factors that increase the risk of developing them, and use functional neuroimaging to predict treatment response and assess treatment-related changes in brain function.
Amygdala, Medial Prefrontal Cortex, and Hippocampal Function in PTSD
- L. Shin, S. Rauch, R. Pitman
- Psychology, BiologyAnnals of the New York Academy of Sciences
- 1 July 2006
Neuroimaging research reveals heightened amygdala responsivity in PTSD during symptomatic states and during the processing of trauma‐unrelated affective information and suggests diminished volumes, neuronal integrity, and functional integrity of the hippocampus in PTSD.
Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study
A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder.
These results provide evidence for exaggerated amygdala responsivity, diminished medial prefrontal cortexresponsivity, and a reciprocal relationship between these 2 regions during passive viewing of overtly presented affective stimuli unrelated to trauma in PTSD.
Neurocircuitry models of posttraumatic stress disorder and beyond: A meta-analysis of functional neuroimaging studies
The Multi-Source Interference Task: validation study with fMRI in individual subjects
The MSIT's reaction time interference effect was up to 10 times greater than that of its component predecessors and temporally stable over hundreds of trials, making the MSIT a useful task with which to study normal human cognition and psychiatric pathophysiology.
Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD.
A reciprocal relationship between medial prefrontal cortex and amygdala function in PTSD and opposing associations between activity in these regions and symptom severity consistent with current functional neuroanatomic models of this disorder are suggested.