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Phenanthroindolizidine alkaloids from the stems of Ficus septica.
Eight new alkaloids, namely, ficuseptines B-D (1-3), 10R,13aR-tylophorine N-oxide (4, 5, 6, 7, and 8), and 10S, 13aS-isotylocrebrine (8) were isolated from a methanol extract of the stems of Ficus septica by means of spectroscopic data interpretation.
Antioxidant properties of royal jelly associated with larval age and time of harvest.
The time of harvest and the initial larval age did affect the antioxidant potencies in RJ, and RJ collected 24 h after the larval transfer showed the most substantial antioxidant activities.
Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.
Three new beta-carboline alkaloids were isolated from the roots of Eurycoma longifolia and demonstrated significant cytotoxicity against human lung cancer and human breast cancer cell lines.
Cytotoxic phenanthroindolizidine alkaloids from the roots of Ficus septica.
Activity-monitored fractionation of the CHCl3 solubles of the MeOH extract of the roots of Ficus septica using cytotoxicity assay led to the isolation of twenty phenanthroindolizidine alkaloids,
Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria.
Five compounds showed significant cytotoxic effects against all ten cancer cell lines, with notable potency at the ng/mL level against some cell Lines, which merits further development as clinical trial candidates.
Immunosuppressive iridoids from the fruits of Gardenia jasminoides.
Ten known compounds, including nine iridoids and a second safranal-type monoterpene, were isolated from the fruits of Gardenia jasminoides and showed significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells.
Cardiac glycosides from Antiaris toxicaria with potent cardiotonic activity.
An ethanolic extract of Antiaris toxicaria trunk bark showed potent in vitro cardiotonic effect on isolated guinea pig atria, leading to identification of nine new cardiac glycosides, named antiarosides A-I, antiarotoxinin A, and 18 known compounds.
Magnesium lithospermate B possesses inhibitory activity on Na+,K+-ATPase and neuroprotective effects against ischemic stroke
The results evidently suggest that the cardiac therapeutic effect of Danshen should be at least partly attributed to the effective inhibition of Na+,K+- ATPase by MLB, and that MLB provides anti-ischemic neuroprotection in gerbils subjected to focal ischemia and reperfusion.
Rhodiola crenulata Extract Alleviates Hypoxic Pulmonary Edema in Rats
It is suggested that RCE confers effective protection for maintaining the integrity of the alveolar-capillary barrier by alleviating the elevated ET-1 and VEGF levels; it does so by reducing hypoxia-induced oxidative stress.