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Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp.
TLDR
Four herbal constituents demonstrated inhibition of P-gp to specific extents in vitro and in vivo as well as related inhibitory mechanisms that provided the basis for the reliable assessment of the potential risks of herb-drug interactions in humans. Expand
Simultaneous quantification of four active schisandra lignans from a traditional Chinese medicine Schisandra chinensis(Wuweizi) in rat plasma using liquid chromatography/mass spectrometry.
TLDR
The method was successfully applied to the pharmacokinetic study of the four lignans after oral administration of Schisandra chinensis extraction to rats and all analytes were proved to be stable during all sample storage, preparation and analytic procedures. Expand
Simultaneous quantification of capsaicin and dihydrocapsaicin in rat plasma using HPLC coupled with tandem mass spectrometry.
TLDR
A rapid, simple and sensitive HPLC-ESI-MS/MS method was developed for the simultaneous determination of capsaicin and dihydrocapsaicin in rat plasma and the analytes were proved to be stable during all sample storage, preparation and analytic procedures. Expand
Simultaneous quantification of three active alkaloids from a traditional Chinese medicine Ramulus Mori (Sangzhi) in rat plasma using liquid chromatography-tandem mass spectrometry.
TLDR
A rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated and successfully applied to the pharmacokinetic study of the three alkaloids in rats after oral administration of the active fraction of alkaloid from mulberry twig. Expand
Essential Role of the Cytochrome P450 Enzyme CYP2A5 in Olfactory Mucosal Toxicity of Naphthalene
TLDR
It is found that the loss of CYP2A5 expression led to substantial decreases in rates of NA metabolic activation by OM microsomes, which further illustrates the tissue-specific nature of the role of individual P450 enzymes in xenobiotic toxicity, and provides the basis for a more reliable assessment of the potential risks of NA nasal toxicity in humans. Expand
A Cinchona Alkaloid Antibiotic That Appears To Target ATP Synthase in Streptococcus pneumoniae.
TLDR
The structure-activity relationships of optochin were examined through modification to both the quinoline and quinuclidine subunits, which led to the identification of analogue 48 with substantially improved activity, providing a foundation to advance 48 and highlight ATP synthase as a promising target for antibiotic development. Expand
Effects of P-glycoprotein on the intestine and blood-brain barrier transport of YZG-331, a promising sedative-hypnotic compound.
TLDR
Results indicated that YZG-331 is a substrate but may not an inhibitor of P-gp, a synthetic adenosine analogue which exhibits the sedative and hypnotic effects by binding to theAdenosine receptor. Expand
In vitro glucuronidation of the primary metabolite of 10-chloromethyl-11-demethyl-12-oxo-calanolide A by human liver microsomes and its interactions with UDP-glucuronosyltransferase substrates.
TLDR
The results suggest that UGT1A1 provides the major contribution to M3 glucuronidation in vitro and M3 has the potential to interact with xenobiotics and endogenous chemicals that are UGT 1A9 and UGT 2B7 substrates. Expand
Kinetic Determination of Lanthanum(III) by the Catalytic Effect on the Oxidation of Fluorescent Safranine Dyes with Potassium Bromate.
TLDR
Comparing the results of two measured reaction systems, it is found that the safranine T reaction system provides high sensitivity and a wider linear range, and is chosen to detect sample water. Expand
Metabolism of IMM-H004 and Its Pharmacokinetic-Pharmacodynamic Analysis in Cerebral Ischemia/Reperfusion Injured Rats
TLDR
It is demonstrated that both prototype and IMM-H004G are the active pharmaceutical substances, and IMm- H004G, at least in part, contributes to the maintenance of anti-cerebral ischemia efficacy of IMM -H004. Expand
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