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ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases
BackgroundUnderstanding the relationship between the millions of functional DNA elements and their protein regulators, and how they work in conjunction to manifest diverse phenotypes, is key toExpand
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Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation
Mammalian oocytes can reprogram somatic cells into a totipotent state enabling animal cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT embryos fail to develop toExpand
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diffReps: Detecting Differential Chromatin Modification Sites from ChIP-seq Data with Biological Replicates
ChIP-seq is increasingly being used for genome-wide profiling of histone modification marks. It is of particular importance to compare ChIP-seq data of two different conditions, such as disease vs.Expand
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Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
TLDR
A genome-wide, whole brain approach to investigate genetic effects on neuroimaging phenotypes for identifying quantitative trait loci is described. Expand
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Identification of common variants associated with human hippocampal and intracranial volumes
Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker ofExpand
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Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
UNLABELLED Small cell lung cancer (SCLC) is an aggressive malignancy distinct from non-small cell lung cancer (NSCLC) in its metastatic potential and treatment response. Using an integrativeExpand
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Weighted Fourier Series Representation and Its Application to Quantifying the Amount of Gray Matter
TLDR
We present a novel weighted Fourier series (WFS) representation for cortical surfaces. Expand
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Identifying quantitative trait loci via group-sparse multitask regression and feature selection: an imaging genetics study of the ADNI cohort
TLDR
We propose a novel Group-Sparse Multi-task Regression and Feature Selection (GSMuRFS) method to identify quantitative trait loci for multiple disease-relevant QTs and apply it to a study in mild cognitive impairment and Alzheimer's disease. Expand
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Tet1 controls meiosis by regulating meiotic gene expression
Meiosis is a germ-cell-specific cell division process through which haploid gametes are produced for sexual reproduction. Before the initiation of meiosis, mouse primordial germ cells undergo aExpand
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Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes.
With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during preimplantation development. Recent studies have suggested that Tet3-mediated oxidation ofExpand
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