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The Cochaperone Bag-1L Enhances Androgen Receptor Action via Interaction with the NH2-Terminal Region of the Receptor
TLDR
Ch chromatin immunoprecipitation studies and surface plasmon resonance and transfection studies showed that the molecular chaperone Hsp70 contributes to the binding of Bag-1L to τ5 and to the regulation of the transactivation function of the androgen receptor. Expand
Overexpression and gene amplification of BAG‐1L in hormone‐refractory prostate cancer
TLDR
The data suggest that amplification and overexpression of BAG‐1L may be involved in the progression of prostate cancer, and protein expression was significantly higher in hormone‐refractory tumours than in primary tumours. Expand
Specific N-terminal mutations in the human androgen receptor induce cytotoxicity
TLDR
The response of the receptors to inhibitors of polyglutamine toxicity is altered by the amino acid exchanges suggesting that careful consideration is needed in the choice of potential therapies of disorders involving toxic polyQ species. Expand
A Peptidic Unconjugated GRP78/BiP Ligand Modulates the Unfolded Protein Response and Induces Prostate Cancer Cell Death
TLDR
A peptide that induces prostate tumor cell death without the need of any conjugating sequences is described, a sequence derived from the cochaperone Bag-1 and it is demonstrated that it modulates the unfolded protein response in ER stress resulting in PARP and caspase-4 cleavage. Expand
Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer
TLDR
It is shown that the activation function-1 (AF-1) domain located in the N-terminus of the androgen receptor (AR) is bound by the cochaperone Bag- 1L, implicating Bag-1L as a potential therapeutic target in PCa. Expand
Abstract A216: Distinct peptides derived from the cochaperone Bag1‐L inhibit prostate cancer cell growth
TLDR
Bag1‐L peptides, which when expressed in prostate tumor cells reduce the growth in vitro as well as in a mouse model of tumor formation, are identified and used as candidate peptides for prostate cancer therapy. Expand
Membrane Localization and Rapid Non-Transcriptional Action of the Androgen Receptor
Androgens play a major role in male sexual development and in prostate growth during later life (for a review, see Brinkman 2001). They function by binding a cytoplasmic androgen receptor (AR) thatExpand
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